货号：ABC25

品牌：Merck Millipore

规格：

目录价：￥4118.00

市场价格：￥3500.30

会员价格：￥3294.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Atg16L1 Antibody | ABC25 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Atg16L1 at the N-terminus. View All» Molecular Weight: ~60 kDa observed. An uncharacterized band may appear at ~15 kDa and 17 kDa in some lysates. View All» Epitope: N-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to the N-terminus of human Atg16L1. View All» Background Information: Atg16L1 (autophagy-related 16-like 1) is a Crohn’s disease susceptibility gene. Atg16L1 is an essential part of the autophagic mechanism that is thought to regulate the endotoxin-induced inflammatory immune response. Atg16L1, in addition with NOD2, is a part of an autophagy-mediated antibacterial pathway that is altered by mutations linked to Crohn’s disease. Recently, Atg16L1 has been linked to an increase in IL-1beta and IL-6 which may be the mechanism for the increased inflammation in Crohn’s disease. View All» Species Reactivity:

• Human

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Human and Rat. Other homologies: Mouse (84% sequence homology). View All» Application Notes: Immunohistochemistry Analysis: A 1:600 dilution from a representative lot detected Atg16L1 in lung squamous cell carcinoma and metastatic liver carcinoma tissues. View All» Control: L6 cell lysate View All» Quality Assurance: Evaluated by Western Blot in L6 cell lysate.Western Blot Analysis: 0.05 µg/mL of this antibody detected Atg16L1 in 10 µg of L6 cell lysate. View All» Purification Method: Affinity Purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q676U5 View All» Entrez Gene Number: NP_110430 View All» Gene Symbol:
  • ATG16L1

  • APG16L
    View All» Alternate Names:
    • Autophagy-related protein 16-1

    • APG16-like 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)
        View All» Entrez Gene Summary: The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene. View All» UniProt Summary: FUNCTION: Plays an essential role in autophagy (By similarity).SUBUNIT STRUCTURE: Homooligomer. Interacts with ATG5. Part of either the minor and major complexes respectively composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa) or 8 sets of ATG12-ATG5 and ATG16L1 (800 kDa) (By similarity).SUBCELLULAR LOCATION: Cytoplasm (By similarity). Preautophagosomal structure membrane; Peripheral membrane protein (By similarity). Note: Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5 (By similarity).INVOLVEMENT IN DISEASE: e Genetic variations in ATG16L1 are associated with susceptibility to inflammatory bowel disease type 10 (IBD10) [MIM:611081]. IBD is characterized by a chronic relapsing intestinal inflammation. IBD is subdivided into Crohn disease (CD) and ulcerative colitis phenotypes. IBD10 individuals show the phenotype characteristic to CD. It may involve any part of the gastrointestinal tract, but most frequently the terminal ileum and colon. CD is commonly classified as autoimmune disease. SEQUENCE SIMILARITIES: Belongs to the WD repeat ATG16 family.Contains 7 WD repeats.SEQUENCE CAUTION: The sequence BAB15448.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.The sequence BAB55412.1 differs from that shown. Reason: Erroneous initiation. View All» Product Name: Anti-Atg16L1 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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