货号：ABC29

品牌：Merck Millipore

规格：

目录价：￥4118.00

市场价格：￥3500.30

会员价格：￥3294.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-ATG4A Antibody | ABC29 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: There are four isoforms with molecular weights of ~45, 38, 36, and 42 kDa that may be observed in different lysates due to alternate splicing. View All» Epitope: Unknown View All» Immunogen: KLH-conjugated linear peptide corresponding to human ATG4A. View All» Background Information: ATG4A (autophagy-related protein 4 A) is a member of the ATG4 family of cysteine proteases that are the objective for oxidation by H2O2 and could be the method for redox regulation of the autophagic procedure. ATG4 is important in cell survival and cell death through autophagy. ATG4A is essential for processing ATG8 which is important in autophagosome biogenesis, specifically the autophagosomal membranes. View All» Species Reactivity:

• Human

• Mouse

• Bovine

• Chimpanzee

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Human. Predicted to react with Mouse, Bovine, Chimpanzee, and Rat based on 100% sequence homology. View All» Control: Human heart tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human heart tissue lysate.Western Blot Analysis: 0.1 µg/mL of this antibody detected ATG4A in 10 µg of human heart tissue lysate. View All» Purification Method: Affinity Purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q8WYN0 View All» Entrez Gene Number: NP_443168 View All» Gene Symbol:
  • ATG4A

  • APG4A

  • AUTL2
    View All» Alternate Names:
    • Cysteine protease ATG4A

    • AUT-like 2 cysteine endopeptidase

    • Autophagin-2

    • Autophagy-related cysteine endopeptidase 2

    • Autophagy-related protein 4 homolog A

    • APG4A
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Transcript variants that encode distinct isoforms have been identified. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. ENZYME REGULATION: Inhibited by N-ethylmaleimide.SUBCELLULAR LOCATION: Cytoplasm Probable. TISSUE SPECIFICTY: Widely expressed, at a low level, and the highest expression is observed in skeletal muscle and brain. Also detected in fetal liver. SEQUENCE SIMILARITIES: Belongs to the peptidase C54 family. View All» Product Name: Anti-ATG4A View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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