货号：ABC32

品牌：Merck Millipore

规格：

目录价：￥4383.00

市场价格：￥3725.55

会员价格：￥3506.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Atg4B View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~45 kDa observed. 5 isoforms are produced by alternative splicing (44 kDa, 52 kDa, 31 kDa, 37 kDa, and 42 kDa). Some unchararterized bands may be observed at ~130 kDa and ~265 kDa in some cell lysates. View All» Immunogen: KLH-conjugated linear peptide corresponding to the human Atg4B. View All» Background Information: Atg4B (autophagy-related protein 4B) is a member of the Atg4 family of C54 endopeptidases that are required for the synthesis of autophagosomes. Atg4B serves as a cysteine-protease that is essential for LC3 lipidation during autophagosome formation and also for de-lipidation during autophagosome recycling. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with Human. Predicted to react with Mouse based on 100% sequence homology. Other homologies: Rat (80% sequence homology). View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected Atg4B in 10 µg of HeLa cell lysate. View All» Purification Method: Affinity Purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9Y4P1 View All» Entrez Gene Number: NP_037457 View All» Gene Symbol: ATG4B, APG4B, AUTL1 View All» Alternate Names:
  • Cysteine protease ATG4B

  • AUT-like 1 cysteine endopeptidase

  • Autophagin-1

  • Autophagy-related cysteine endopeptidase 1Autophagy-related protein 4 homolog B

  • hAPG4B
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. View All» UniProt Summary: FUNCTION: Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.ENZYME REGULATION: Inhibited by N-ethylmaleimide.SUBCELLULAR LOCATION: Cytoplasm.TISSUE SPECIFICITY: Mainly expressed in the skeletal muscle, followed by brain, heart, liver and pancreas. View All» Product Name: Anti-Atg4B View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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