货号：ABC49

品牌：Merck Millipore

规格：EA

目录价：￥3768.00

市场价格：￥3202.80

会员价格：￥3014.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-TDAG51 Antibody | ABC49 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~48 kDa observed View All» Epitope: 0 View All» Immunogen: KLH-conjugated linear peptide corresponding to human TDAG51. View All» Background Information: T-cell death-associated gene 51 (TDAG51) regulates T-cell receptor/CD3-dependent induction of CD95/Fas in murine T cell hybridomas. TDAG51 may play a critical role in T cell apoptosis by coupling TCR stimulation to Fas expression. TDAG51 is specifically induced by IGF-I and plays an important role in the anti-apoptotic effects of IGF-I. View All» Species Reactivity:

• Human

• Rat

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with Human, Rat, and Mouse. View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: 0.1 µg/mL of this antibody detected TDAG51 on 10 µg of HeLa cell lysate. Western Blot performed without Tween. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q8WV24 View All» Entrez Gene Number: NP_031376 View All» Gene Symbol:
  • PHLDA1

  • PHRIP

  • TDAG51
    View All» Alternate Names:
    • Pleckstrin homology-like domain family A member 1

    • Apoptosis-associated nuclear protein

    • proline- and glutamine-rich protein

    • PQ-rich protein

    • PQR protein

    • Proline- and histidine-rich proteinT-cell death-associated gene 51 protein
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1. [provided by RefSeq, Jul 2008]. View All» UniProt Summary: FUNCTION: Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation. SUBUNIT STRUCTURE: Interacts with RPL14, EIF3S7 and PABPC4. SUBCELLULAR LOCATION: Cytoplasm. Cytoplasmic vesicle membrane. Nucleus › nucleolus. Note: Colocalizes with intracellular vesicles. TISSUE SPECIFICITY: Widely expressed with highest levels in pancreas. Strongly expressed by benign melanocytic nevi, and progressively reduced expressed in primary and metastatic melanomas (at protein level). INDUCTION: Induced by homocysteine and other endoplasmic reticulum stress-inducing reagents. Induced by phorbol ester (TPA)/ionomycin, and stimulation of the T-cell receptor (TCR) complex in T-cells. SEQUENCE SIMILARITIES: Contains 1 PH domain.SEQUENCE CAUTION: The sequence AAH18929.3 differs from that shown. Reason: Erroneous initiation. The sequence AAI10821.1 differs from that shown. Reason: Erroneous initiation. The sequence AAI26426.2 differs from that shown. Reason: Erroneous initiation. View All» Product Name: Anti-TDAG51 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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