货号：ABC50

品牌：Merck Millipore

规格：

目录价：￥4383.00

市场价格：￥3725.55

会员价格：￥3506.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Noxa Antibody | ABC50 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Noxa at the N-terminus. View All» Molecular Weight: 7 kDa calculated. Possible ubiquitination may result in observed higher molecular weights (Baou, M., et al. (2010). Haematologica. 95(9):1510-1518). View All» Epitope: N-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to human Noxa at the N-terminus. View All» Background Information: Noxa, a BH3-only protein, is induced in response to apoptotic stimuli such as DNA damage, hypoxia, and proteasome inhibition and required for apoptosis in response to glucose stress. Noxa is constitutively expressed in proliferating hematopoietic lineage cells. The expression of Noxa involves direct activation of its promotor by p53 and studies demonstated that the blocking of endogenous Noxa induction results in the suppression of apoptosis thereby suggesting that Noxa represents a mediator of p53 dependent apoptosis. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. Predicted to react with Orangutan based on 100% sequence homology. View All» Application Notes: Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected Noxa in neurons in normal human brain tissue. View All» Control: Osteoblasts in human bone tissue View All» Quality Assurance: Evaluated by Immunohistochemistry in osteoblasts in human bone tissue.Immunohistochemistry Analysis: A 1:200 dilution of this antibody detected Noxa in osteoblasts in human bone tissue. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q13794 View All» Entrez Gene Number: NP_066950 View All» Gene Symbol:

• PMAIP1

• NOXA
  View All» Alternate Names:
  • Phorbol-12-myristate-13-acetate-induced protein 1

  • PMA-induced protein 1

  • Immediate-early-response protein APR

  • Protein Noxa
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunohistochemistry View All» UniProt Summary: FUNCTION: Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. SUBUNIT STRUCTURE: Interacts with MCL1 and BAX. SUBCELLULAR LOCATION: Mitochondrion TISSUE SPECIFICITY: Highly expressed in adult T-cell leukemia cell line.INDUCTION: Up-regulated by p53/TP53, phorbol esters, double-stranded RNA, IFNB1/IFN-beta and viruses. DOMAIN: The BH3 motif is essential for pro-apoptotic activity.SEQUENCE SIMILARITIES: Belongs to the PMAIP1 family. View All» Product Name: Anti-Noxa View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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