货号：ABC53

品牌：Merck Millipore

规格：

目录价：￥4439.00

市场价格：￥3773.15

会员价格：￥3551.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Bcl-2 interacting killer (BIK) Antibody | ABC53 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody detects Bcl-2 interacting killer in highly apoptotic tissues and cells. View All» Molecular Weight: ~18 kDa observed. An uncharacterized band at ~37 kDa may be observed in some cell lysates. View All» Immunogen: KLH-conjugated linear peptide corresponding to human Bcl-2 interacting killer. View All» Background Information: Bcl-2-interacting killer (BIK), also known by other names (Apoptosis inducer NBK; BIP1; BP4), is predominantly found in the ER membrane, and is expressed in response to DNA damage, cytokine release, and viral infection. In the absence of activated cell-survival proteins, BIK interacts with death-promoting proteins such as Bax, and suppresses anti-apoptotic BCL2 proteins, to accelerate mitochondrial apoptosis. BIK directly increases calcium release from the ER and remodeling of the mitochondrial cristae. BIK may be regulated by post-translational modifications produced from a STAR-PAP/ PKCδ pathway, and the corresponding gene, BIK, may be silenced by epigenetic mechanisms in various forms of cancer. BIK may therefore play a role as a tumor suppressor. View All» Species Reactivity: Rat View All» Species Reactivity Note: Demonstrated to react with Rat. Predicted to react with Human based on immunogen design. View All» Control: Raji cell lysate View All» Quality Assurance: Evaluated by Western Blot in Raji cell lysate.Western Blot Analysis: 0.86 µg/mL of this antibody detected Bcl-2 interacting killer in 10 µg of Raji cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q13323 View All» Entrez Gene Number: NP_001188 View All» Gene Symbol:

• BIK

• NBK
  View All» Alternate Names:
  • Bcl-2-interacting killer

  • Apoptosis inducer NBK

  • BIK1

  • BP4
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Product Name: Anti-Bcl-2 interacting killer (BIK) View All» Concentration: 0.86 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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