货号：ABC69

品牌：Merck Millipore

规格：

目录价：￥4264.00

市场价格：￥3624.40

会员价格：￥3411.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Apoptosis-inducing factor 2 (AIFM2) Antibody | ABC69 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~45 kDa observed. Uncharacterized bands appear at ~95 kDa and ~300 kDa in some lysates. View All» Immunogen: KLH-conjugated linear peptide corresponding to human Apoptosis inducing factor 2. View All» Background Information: Apoptosis inducing factor 2 (AIFM2) is a flavoprotein oxidoreductase that binds to DNA in a sequence-independent manner and is a member of the FAD-dependent oxidoreductase family. Apoptosis inducing factor 2 is widely expressed in the heart and, to a much lesser extent, the liver and skeletal muscles. Overexpression of Apoptosis inducing factor 2 has been shown to induce apoptosis. View All» Species Reactivity:

• Mouse

• Human
  View All» Species Reactivity Note: Demonstrated to react with Mouse. Predicted to react with Human based on 100% sequence homology. View All» Control: C2C12 cell lysate View All» Quality Assurance: Evaluated by Western Blot in C2C12 cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected Apoptosis inducing factor 2 on 10 µg of C2C12 cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9BRQ8 View All» Entrez Gene Number: NP_116186 View All» Gene Symbol:
  • AIFM2

  • AMID

  • PRG3
    View All» Alternate Names:
    • Apoptosis-inducing factor 2

    • Apoptosis-inducing factor homologous mitochondrion-associated inducer of death

    • Apoptosis-inducing factor-like mitochondrion-associated inducer of death

    • p53-responsive gene 3 protein
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a flavoprotein oxidoreductase that binds single stranded DNA and is thought to contribute to apoptosis in the presence of bacterial and viral DNA. The expression of this gene is also found to be induced by tumor suppressor protein p53 in colon cancer cells. [provided by RefSeq, Nov 2010]. View All» UniProt Summary: FUNCTION: Oxidoreductase, which may play a role in mediating a p53/TP53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Binds to DNA in a sequence-independent manner. May contribute to genotoxin-induced growth arrest.COFACTOR: FAD. Binds 6-hydroxy-FAD non-covalently. SUBCELLULAR LOCATION: Cytoplasm. Mitochondrion outer membrane TISSUE SPECIFICITY: Detected in most normal tissues as two transcripts of 1.8 and 4.0 kb in length, respectively. Highly expressed in heart, moderately in liver and skeletal muscles, and expressed at low levels in placenta, lung, kidney, and pancreas. Both transcripts expressed following p53/TP53 induction. The shorter 1.8 kb transcript seems to be the major transcript in EB1 colon cancer cells. INDUCTION: Expression detected at 4 hours after induction by p53/TP53. Down-regulated in a wide range of human tumors. SEQUENCE SIMILARITIES: Belongs to the FAD-dependent oxidoreductase family. View All» Product Name: Anti-Apoptosis-inducing factor 2 (AIFM2) View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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