货号：ABC83

品牌：Merck Millipore

规格：100UL

目录价：￥5126.00

市场价格：￥4357.10

会员价格：￥4100.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Angptl3 Antibody | ABC83 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the coiled coil region of Angptl3. View All» Molecular Weight: ~70 kDa observed. The calculated molecular weight of this protein is 54 kDa, but can be observed at ~70 kDa due to high glycosylation. (Shimizugawa, t., et al. (2002). Journal of Biological Chemistry. 277:33742-33748.) View All» Epitope: 0 View All» Immunogen: GST-tagged recombinant protein corresponding to the coiled coil region of mouse Angptl3. View All» Background Information: The protein encoded by this gene is a member of the angiopoietin-like family of secreted factors. It is predominantly expressed in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-Terminal coiled coil domain and the C terminal Fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha 5 beta 3 integrins, and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis. Angptl3 also acts as dual inhibitor of lipoprotein lipase (LPL) and endothelial lipase (EL), and increases plasma triglyceride and HDL cholesterol in rodents. Angptl3 inhibit endothelial lipase to catalyze HDL-phospholipid and increase HDL-PL levels. Circulating PL-rich HDL particles have high cholesterol efflux abilities. Defects in Angptl3 are the cause of familial hypobetalipoproteinemia type 2 (FHBL2) also called combined hypobetalipoproteinemia familial. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Human, Mouse, and Rat. View All» Application Notes: Immunohistochemistry Analysis: A 1:100-500 dilution from a representative lot detected Angptl3 in human liver, human cardiac myocytes, mouse liver, rat liver, and rat kidney tissues. View All» Control: HepG2 cell lysate View All» Quality Assurance: Evaluated by Western Blot in HepG2 cell lysate.Western Blot Analysis: A 1:1,000 dilution of this antibody detected Angptl3 in 10 µg of HepG2 cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9R182 View All» Entrez Gene Number: NP_038941 View All» Gene Symbol: Angptl3 View All» Alternate Names:
  • Angiopoietin-related protein 3

  • Angiopoietin-like protein 3
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunofluorescence

    • Immunohistochemistry (Paraffin)
      View All» Product Name: Anti-Angptl3 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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