货号：ABC88

品牌：Merck Millipore

规格：100Ug

目录价：￥3898.00

市场价格：￥3313.30

会员价格：￥3118.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-FK506-binding protein-like (FKBPL) Antibody | ABC88 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes FK506-binding protein-like at the TPR1 region. View All» Molecular Weight: ~50 kDa observed. The calculated molecular weight is 38 kDa, however FK506-binding protein-like has been shown as a ~48 kDa band in western blots. (McKeen, H., et al. (2008). Endocrinology 149(11):5724–5734.) View All» Epitope: TPR1 region View All» Immunogen: KLH-conjugated linear peptide corresponding to human FK506-binding protein-like at the TPR1 region. View All» Background Information: FK506-binding protein-like (FKBPL) belongs to the family of FK506 binding proteins and is an immunophilin-like protein that plays a role in immunoregulation and the cellular stress response. It is ubiquitously expressed with higher levels in testis. Mutations in FK506-binding protein-like have been associated with human infertility. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Bovine

• Rhesus Macaque
  View All» Species Reactivity Note: Demonstrated to react with Human, Mouse, and Rat. Predicted to react with Bovine and Rhesus Macaque based on 100% sequence homology. View All» Application Notes: Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected FK506-binding protein-like in human prostate amd rat testis tissues. View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: 0.05 µg/mL of this antibody detected FK506-binding protein-like on 10 µg of HeLa cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9UIM3 View All» Entrez Gene Number: NP_071393 View All» Gene Symbol:
  • FKBPL

  • DIR1

  • NG7
    View All» Alternate Names:
    • FK506-binding protein-like

    • WAF-1/CIP1 stabilizing protein 39

    • WISp39
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)
        View All» Entrez Gene Summary: The protein encoded by this gene has similarity to the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The encoded protein is thought to have a potential role in the induced radioresistance. Also it appears to have some involvement in the control of the cell cycle. [provided by RefSeq, Jul 2008]. View All» UniProt Summary: FUNCTION: May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21. TISSUE SPECIFICITY: Ubiquitously expressed with higher levels in testis. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SEQUENCE SIMILARITIES: Contains 3 TPR repeats.SEQUENCE CAUTION: The sequence BAB15663.1 differs from that shown. Reason: Frameshift at positions 201, 205 and 319. The sequence CAG33655.1 differs from that shown. Reason: Frameshift at position 201. View All» Product Name: Anti-FK506-binding protein-like (FKBPL) View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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