货号：ABC89

品牌：Merck Millipore

规格：

目录价：￥4502.00

市场价格：￥3826.70

会员价格：￥3601.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Netrin receptor UNC5B Antibody | ABC89 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~103 kDa observed. Uncharacterized bands at ~52 kDa and ~150 kDa may be observed in some cell lysates. View All» Immunogen: KLH-conjugated branch peptide corresponding to humna Netrin receptor UNC5B. View All» Background Information: Netrin receptor UNC5B is required for axonal guidance and growth, embryonic development, angiogenesis, and vascular patterning, among other related functions. In general, netrins are bifunctional guidance cues, which either attract or repel axons. Attraction and repulsion is mediated by the activation of colorectal cancer (DCC) and uncoordinated 5 (UNC5) receptor families, respectively. The UNC5 receptor family consists of four members, UNC5A to UNC5D. Additionally, Netrin recpetor UNC5B acts as a dependence receptor that is required for apoptosis induction when not associated with netrin ligand. It is suggested to play a role in certain abnormal processes such as cancer. View All» Species Reactivity:

• Mouse

• Human
  View All» Species Reactivity Note: Demonstrated to react with Mouse. Predicted to react with Human based on 100% sequence homology. View All» Control: Mouse brain membrane tissue lysate. View All» Quality Assurance: Evaluated by Western Blot in mouse brain membrane tissue lysate.Western Blot Analysis: 2 µg/mL of this antibody detected Netrin receptor UNC5B in 10 µg of mouse brain membrane tissue lysate. This antibody has only been demonstrated to work in membrane preparations. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q8IZJ1 View All» Entrez Gene Number: NP_734465 View All» Gene Symbol:
  • UNC5B

  • P53RDL1

  • UNC5H2
    View All» Alternate Names:
    • Netrin receptor UNC5B

    • Protein unc-5 homolog 2

    • Protein unc-5 homolog B

    • p53-regulated receptor for death and life protein 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene. View All» UniProt Summary: FUNCTION: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.SUBUNIT STRUCTURE: Interacts with the cytoplasmic part of DCC (By similarity). Interacts with GNAI2 via its cytoplasmic part.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney and hematopoietic and immune tissues. View All» Product Name: Anti-Netrin receptor UNC5B View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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