货号：ABD12

品牌：Merck Millipore

规格：100Ug

目录价：￥5359.00

市场价格：￥4555.15

会员价格：￥4287.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Aldehyde dehydrogenase 1 (ALDH1A1) Antibody | ABD12 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~54 kDa observed View All» Immunogen: KLH-conjugated linear peptide corresponding to human Aldehyde dehydrogenase 1. View All» Background Information: Aldehyde dehydrogenase 1A1 (ALDH1A1) is also known as retinal dehydrogenase 1. It is thought to be a main converter of retinol to retinoic acid, which is very important in cell to cell signaling. ALDH1A1 may also be involved in inhibiting invasion in pancreatic cancer cells. More specifically, ALDH1A1 may regulate hematopoietic stem cell differentiation by disrupting the retinoid signaling. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. Other homologies: rat and mouse (91% sequence homology). View All» Control: HepG2 cell lysate View All» Quality Assurance: Evaluated by Western Blot in HepG2 cell lysate.Western Blot Analysis: 0.05 µg/mL of this antibody detected Aldehyde dehydrogenase 1 on 10 µg of HepG2 cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P00352 View All» Entrez Gene Number: NP_000680 View All» Gene Symbol:

• RALDH1

• ALDH11

• ALHDII

• ALDC

• ALDH-E1

• ALDH1

• PUMB1

• RalDH1

• RALDH 1

• ALDH1A1
  View All» Alternate Names:
  • aldehyde dehydrogenase 1 family, member A1

  • ALDH class 1

  • Aldehyde dehydrogenase, cytosolic

  • retinaldehyde dehydrogenase 1

  • Aldehyde dehydrogenase family 1 member A1

  • retinal dehydrogenase 1

  • acetaldehyde dehydrogenase 1

  • aldehyde dehydrogenase 1, soluble

  • aldehyde dehydrogenase, liver cytosolic
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a cytosolic isoform, which has a high affinity for aldehydes. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity).CATALYTIC ACTIVITY: Retinal + NAD+ + H2O = retinoate + NADH.PATHWAY: Cofactor metabolism; retinol metabolism.SUBUNIT STRUCTURE: Homotetramer.SUBCELLULAR LOCATION: Cytoplasm. SEQUENCE SIMILARITIES: Belongs to the aldehyde dehydrogenase family. View All» Product Name: Anti-Aldehyde dehydrogenase 1 (ALDH1A1) View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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