货号：ABD13

品牌：Merck Millipore

规格：

目录价：￥4146.00

市场价格：￥3524.10

会员价格：￥3316.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Cripto-1 Antibody | ABD13 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~18 kDa and ~35 kDa observed. An uncharacterized band may appear at ~62 kDa in some lysates. The observed molecular weight at ~35 kDa may be the result of glycosylsation. (Brandt, R., et al. (1994). The Journal of Biological Chemistry. 269(25):17320-17328.) View All» Immunogen: KLH-conjugated linear peptide corresponding to human Cripto-1. View All» Background Information: Cripto-1 growth factor (Cripto-1), also known as teratocarcinoma-derived growth factor 1 (TDGF1), is a member of the epidermal growth factor-CFC family and is important for embryonic development. Cripto-1 has been shown to be up-regulated in many different human cancers and could be a possible therapeutic target for cancer. There is also promising research surrounding a cancer vaccine that uses Cripto-1 as a target. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. No homology to Mouse or Rat found. View All» Control: NT2/D1 cell lysate View All» Quality Assurance: Evaluated by Western Blot in NT2/D1 cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected Cripto-1 on 10 µg of NT2/D1 cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P13385 View All» Entrez Gene Number: NP_003203 View All» Gene Symbol:

• TDGF1

• CRIPTO
  View All» Alternate Names:
  • Teratocarcinoma-derived growth factor 1

  • Cripto-1 growth factor

  • CRGF

  • Epidermal growth factor-like cripto protein CR1

  • TDGF1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor › GPI-anchor TISSUE SPECIFICTY: Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts.SEQUENCE SIMILARITIES: Contains 1 EGF-like domain. View All» Product Name: Anti-Cripto-1 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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