货号：ABD18

品牌：Merck Millipore

规格：EA

目录价：￥3732.00

市场价格：￥3172.20

会员价格：￥2985.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-GDF-3 Antibody | ABD18 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes GDF-3 at the propeptide domain. View All» Molecular Weight: ~44 kDa observed View All» Epitope: Propeptide domain View All» Immunogen: KLH-conjugated linear peptide corresponding to the propeptide domain of human GDF-3. View All» Background Information: Growth differentiation factor-3 (GDF3), also known as Vg-related gene 2 (Vgr-2), belongs to the transforming growth factor beta (TGF-β) superfamily. Expression of GDF3 occurs in ossifying bones during embryonic development and in the brain, thymus, spleen, bone marrow, and adipose tissue of adults. GDF3 regulates the balance between different modes of TGF-β signaling. Studies have shown GDF3 to control differentiation of embyronic stem cells in mice and humans. View All» Species Reactivity:

• Human

• Mouse

• Chimpanzee
  View All» Species Reactivity Note: Demonstrated to react with Human and Mouse. Predicted to react with Chimpanzee based on 100% sequence homology. View All» Application Notes: Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected GDF-3 in H9 human embryonic stem cells. View All» Control: H9 human embryonic stem cell lysate View All» Quality Assurance: Evaluated by Western Blot in H9 human embryonic stem cell lysate.Western Blot Analysis: 0.05 µg/mL of this antibody detected GDF-3 on 10 µg of H9 human embryonic stem cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9NR23 View All» Entrez Gene Number: NP_065685 View All» Gene Symbol: GDF3 View All» Alternate Names:
  • Growth/differentiation factor 3

  • GDF-3
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry
      View All» Entrez Gene Summary: The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. [provided by RefSeq, Jul 2008]. View All» UniProt Summary: SUBUNIT STRUCTURE: Homodimer or heterodimer Potential. But, in contrast to other members of this family, cannot be disulfide-linked.SUBCELLULAR LOCATION: Secreted Probable. INVOLVEMENT IN DISEASE: Defects in GDF3 are the cause of Klippel-Feil syndrome type 3 (KFS3) [MIM:613702]; also called Klippel-Feil syndrome autosomal dominant 3. KFS3 is a skeletal disorder characterized by congenital fusion of cervical vertebrae. It is due to a failure in the normal segmentation of vertebrae during the early weeks of fetal development. The clinical triad consists of short neck, low posterior hairline, and limited neck movement. Defects in GDF3 are the cause of microphthalmia isolated with coloboma type 6 (MCOPCB6) [MIM:613703]; also called isolated colobomatous microphthalmia 6. MCOPCB6 is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataract and other abnormalities like cataract may also be present. Ocular colobomas are a set of malformations resulting from abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Defects in GDF3 are a cause of microphthalmia isolated type 7 (MCOP7) [MIM:613704]. MCOP7 is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataract and other abnormalities like cataract may also be present. SEQUENCE SIMILARITIES: Belongs to the TGF-beta family. View All» Product Name: Anti-GDF-3 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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