货号：ABD26

品牌：Merck Millipore

规格：

目录价：￥4146.00

市场价格：￥3524.10

会员价格：￥3316.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SLAM (CD150) Antibody | ABD26 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the potential SH2 binding domain of SLAM. View All» Molecular Weight: ~70 kDa observed. The calculated molecular weight is 37 kDa. A molecular weight band of ~70 kDa is due to glycosylation (Castro., A.G., et al. (1999). J Immunol. 163(11):5860-5870). Uncharacterized bands may be seen at ~10 kDa and ~200 kDa in some cell lysates. View All» Epitope: Potential SH2 binding domain. View All» Immunogen: KLH-conjugated linear peptide corresponding to the potential SH2 binding domain of human SLAM. View All» Background Information: Signaling lymphocyte activation molecule (SLAM) family member 1 (also known as CD150) is a self-ligand cell surface glycoprotein expressed on T cells, B cells, macrophages, and dendritic cells. CD150 plays an important role in adhesion and signaling between T cells and antigen-presenting cells (APCs), and it is involved in two major immune functions: costimulation of T-cell proliferation and augmentation of interferon response. CD150 is the prototypical member of a growing family of glycoprotein receptors on hematopoietic stem cells known as the SLAM family, which includes CD229, CD84, CD244, SF2000/Ly108, SF2001, and 19A(CRACC). Members of this family are defined by one or more cytoplasmic tyrosine motifs. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. Other homologies: Rat and Mouse (75% sequence homology). View All» Control: Human spleen tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human spleen tissue lysate.Western Blot Analysis: 5 µg/mL of this antibody detected SLAM in human spleen tissue lysate. View All» Purification Method: Affinity Purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q13291 View All» Entrez Gene Number: NP_003028 View All» Gene Symbol:

• SLAMF1

• SLAM
  View All» Alternate Names:
  • Signaling lymphocytic activation molecule

  • CDw150

  • IPO-3

  • CD_antigen=CD150
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.SUBUNIT STRUCTURE: Interacts (via cytoplasmic domain) with SH2D1A, and with PTPN11. Interacts with INPP5D/SHIP1. Binds to Measles virus H protein and acts as a receptor for this virus.SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Note: Present on the surface of B-cells and T-cells. View All» Product Name: Anti-SLAM (CD150) View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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