货号：ABD28

品牌：Merck Millipore

规格：100UL

目录价：￥4659.00

市场价格：￥3960.15

会员价格：￥3727.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Rfx6 Antibody | ABD28 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: 102 kDa calculated. Additional isoforms at 59 and 73 kDa have also been reported. View All» Immunogen: GST-tagged recombinant protein corresponding to mouse Rfx6. View All» Background Information: Rfx6 (regulatory factor X 6) is a winged-helix transcription factor that is essential for development and seems to be located exclusively in the pancreatic islets. It has been associated with endoderm development, specifically, and the differentiation of islet cells. Since insulin production happens in the beta-cells of pancreatic islets, Rfx6 may be used clinically to treat diabetes. Recently, Rfx6 function has been found to change over time and gets restricted to endocrine cells at later stages. Mitchell-Riley syndrome is thought to stem from a Rfx6 mutation. View All» Species Reactivity: Mouse View All» Species Reactivity Note: Demonstrated to react with Mouse. View All» Control: Mouse embryo pancreas tissue View All» Quality Assurance: Evaluated by Immunohistochemistry in mouse embryo pancreas tissue.Immunohistochemistry Analysis: 1:400 dilution of this antibody detected Rfx6 in mouse embryo pancreas tissue. View All» Purification Method: Unpurified View All» Presentation: Rabbit polyclonal serum containing 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q8C7R7 View All» Entrez Gene Number: NP_001152861 View All» Gene Symbol:

• Rfx6

• Rfxdc1
  View All» Alternate Names:
  • DNA-binding protein RFX6

  • Regulatory factor X 6

  • Regulatory factor X domain-containing protein 1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunohistochemistry View All» UniProt Summary: FUNCTION: Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin. Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes. SUBUNIT STRUCTURE: Interacts with RFX3. SUBCELLULAR LOCAION: Nucleus TISSUE SPECIFICTY: In the adult pancreas, expression is restricted to the islets where it could be detected in all endocrine lineages. DEVELOPMENTAL STAGE: Expressed initially broadly in the definitive endoderm after gastrulation, becomes restricted to the gut and pancreatic bud at mid gestation, and is reactivated by Neurog3 in islet progenitor cells and is ultimately restricted to pancreatic islets in the mature pancreas (at protein level). INDUCTION: By Neurog3. DISRUPTION PHENOTYPE: Mice were born at the expected Mendelian ratio, but fail to feed normally, exhibit gross bowel distension due to small bowel obstruction and die within 2 days post partum. Some, but not all, of the animals also have reduced pancreas size. pancreata had almost no expression of the islet hormones genes, except for PP (polypeptide-producing). SEQUENCE SIMILARITIES: Belongs to the RFX family.Contains 1 H-T-H motif winged-type DNA-binding domain.SEQUENCE CAUTION: The sequence AAI32105.1 differs from that shown. Reason: Erroneous initiation. The sequence AAI32295.1 differs from that shown. Reason: Erroneous initiation. View All» Product Name: Anti-Rfx6 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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