货号：ABD31

品牌：Merck Millipore

规格：

目录价：￥4264.00

市场价格：￥3624.40

会员价格：￥3411.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-DAZL Antibody | ABD31 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~33 kDa observed View All» Epitope: 0 View All» Immunogen: KLH-conjugated linear peptide corresponding to human DAZL. View All» Background Information: DAZL (Deleted in azoospermia-like 1; SPGY-like-autosomal) is an RNA-binding protein that interacts with mRNA transcripts by its N-terminal RNA recognition motifs. It is the product of the Y-linked DAZ gene, and is found exclusively in the testes. DAZL regulates gene expression during spermatogenesis and may shuttle between the nucleus and cytoplasm during various stages of this process. It interacts with other proteins of the DAZ family via its DAZ-like domain, including DAZ, BOLL, DAZAP1, DAZAP2, and PUM2. Disruption of DAZL expression may play a role in male infertility. View All» Species Reactivity:

• Human

• Rat

• Mouse

• Bovine
  View All» Species Reactivity Note: Demonstrated to react with Human and Rat. Predicted to react with Mouse and Bovine based on 100% sequence homology. View All» Application Notes: Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected DAZL in rat and human testis cancer tissue. View All» Control: Human testis tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human testis tissue lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected DAZL in 10 µg of human testis tissue lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q92904 View All» Entrez Gene Number: NP_001342 View All» Gene Symbol:
  • DAZL

  • DAZH

  • DAZL1

  • DAZLA

  • SPGYLA
    View All» Alternate Names:
    • Deleted in azoospermia-like

    • DAZ homolog

    • DAZ-like autosomal

    • Deleted in azoospermia-like 1

    • SPGY-like-autosomal
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)
        View All» Entrez Gene Summary: The DAZ (Deleted in Azoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males. Two transcript variants encoding different isoforms have been found for this gene. View All» UniProt Summary: FUNCTION: RNA-binding protein, which is essential for gametogenesis. Plays a central role during spermatogenesis. May act by binding to the 3'-UTR of mRNA and thereby regulating the translation of key transcripts.SUBUNIT STRUCTURE: Homodimer and heterodimer. Forms a heterodimer with DAZ. Interacts with BOLL, DAZAP1 and DAZAP2. Interacts with PUM2.SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note: Predominantly cytoplasmic. Nuclear in spermatogonia until near the end of the meiotic prophase and cytoplasmic localization from then onward.TISSUE SPECIFICITY: Testis specific.DOMAIN: The DAZ-like domain mediates the interaction with DAZAP1 and DAZAP2.SEQUENCE SIMILARITIES: Belongs to the RRM DAZ family. Contains 1 DAZ-like domain. Contains 1 RRM (RNA recognition motif) domain. View All» Product Name: Anti-DAZL View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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