货号：ABD32

品牌：Merck Millipore

规格：

目录价：￥3916.00

市场价格：￥3328.60

会员价格：￥3132.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-B-myb Antibody | ABD32 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes b-myb at the HTH myb-type 1 domain. View All» Molecular Weight: ~95 kDa observed. Calculated molecular weight of 79 kDa; however B-myb has been observed at ~95 kDa (Tarasov, K.V., et al. (2008). PLoS One. 3(6):e2478.) View All» Epitope: HTH myb-type 1 domain View All» Immunogen: KLH-conjugated linear peptide corresponding to human B-myb at the HTH myb-type 1 domain. View All» Background Information: Myb is a transcriptional activator and a proto-oncogene protein that specifically recognizes the sequence 5'-YAAC[GT]G-3'. B-myb plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. Studies suggest that it also may play a role in tumorigenesis. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with Human and Mouse. Other homologies: Rat and Bovine (91% sequence homology). View All» Application Notes: Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected B-myb in mouse embryonic stem cells. View All» Control: Mouse embryonic stem cell lysate View All» Quality Assurance: Evaluated by Western Blot in mouse embryonic stem cell lysate.Western Blot Analysis: 0.2 µg/mL of this antibody detected B-myb on 10 µg of mouse embryonic stem cell lysate. View All» Purification Method: Affinity Purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P10244 View All» Entrez Gene Number: NP_002457 View All» Gene Symbol:
  • MYBL2

  • BMYB
    View All» Alternate Names:
    • Myb-related protein B

    • B-Myb

    • Myb-like protein 2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry
        View All» Entrez Gene Summary: The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Transcript variants may exist for this gene, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]. View All» UniProt Summary: FUNCTION: Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.SUBUNIT STRUCTURE: Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL22.SUBCELLULAR LOCATION: Nucleus. PTM: Phosphorylated by cyclin A/CDK2 during S-phase. Phosphorylation at Thr-520 is probably involved in transcriptional activity. SEQUENCE SIMLARITIES: Contains 3 HTH myb-type DNA-binding domains. View All» Product Name: Anti-B-myb View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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