货号：ABD41

品牌：Merck Millipore

规格：

目录价：￥4264.00

市场价格：￥3624.40

会员价格：￥3411.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Lymphoid-specific helicase (HELLS) Antibody | ABD41 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the coiled-coil region of Lymphoid-specific helicase. View All» Molecular Weight: ~95 kDa observed. Nine isoforms are produced by alternative splicing with molecular weights at ~97, 95, 93, 90, 85, 81, 39, 36 and 14 kDa. Uncharacterized bands may be observed at ~35 kDa and ~60 kDa in some cell lysates. View All» Epitope: Coiled-coil region View All» Immunogen: KLH-conjugated linear peptide corresponding to the coiled-coil region of human Lymphoid-specific helicase. View All» Background Information: A member of the SNF2 family of chromatin remodeling proteins, Lymphoid-specific helicase (HELLS, also known as Lsh) assumes various roles in normal development, survival, de novo or maintenance DNA methylation, gene silencing, and heterochromatin formation and organization. It is shown to serve as cancer progression marker in conjunction with CEP55 and FOXM1 for the detection of head and neck squamous cell carcinoma (HNSCC). It is also reported that expression of Lsh is crucial for meiotic progression in mouse spermatocytes. Lsh is shown to directly associate with the 5' DMR of the Cdkn1c promoter, and thereby regulate its gene expression. Additionally, Lsh is reported as a regulator of repressive chromatin at retrotransposons, and is demonstrated to mediate the silencing of stem cell-specific genes such as Oct4. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Human, Mouse, and Rat. View All» Application Notes: Western Blot Analysis: 0.1 µg/mL from a representative lot detected Lymphoid-specific helicase in NIH/3T3 and L6 cell lysates.Immunocytochemistry Analysis: 2 µg/mL from a representative lot detected Lymphoid-specific helicase in NIH/3T3, A431, and HeLa cells. View All» Control: HeLa nuclear extract View All» Quality Assurance: Evaluated by Western Blot in HeLa nuclear extract.Western Blot Analysis: 0.1 µg/mL of this antibody detected Lymphoid-specific helicase in HeLa nuclear extract. View All» Purification Method: Affinity Purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9NRZ9 View All» Entrez Gene Number: NP_060533 View All» Gene Symbol:
  • HELLS

  • PASG

  • SMARCA6
    View All» Alternate Names:
    • LSH

    • Lymphoid-specific helicase

    • Proliferation-associated SNF2-like protein

    • SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry
        View All» Entrez Gene Summary: This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. View All» UniProt Summary: FUNCTION: Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis.SUBCELLULAR LOCATION: Nucleus. Note: Closely associated with pericentric heterochromatin.TISSUE SPECIFICITY: Highly expressed in proliferative tissues such as adult thymus and testis, and expressed at lower levels in uterus, small intestine, colon, and peripheral blood mononuclear cells. Also expressed in neoplastic cell lines including those derived from myeloid and lymphoid leukemias. View All» Product Name: Anti-Lymphoid-specific helicase (HELLS) View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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