货号：ABD49

品牌：Merck Millipore

规格：

目录价：￥4264.00

市场价格：￥3624.40

会员价格：￥3411.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Pw1/Peg3 Antibody | ABD49 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: Three isoforms produced by alternative splicing at a calculated molecular weight of 181 kDa, 166 kDa, and 61 kDa. View All» Epitope: 0 View All» Immunogen: KLH-conjugated linear peptide corresponding to human Pw1/Peg3. View All» Background Information: Pw1/Peg3 plays a role in certain cellular processes, such as cell death and growth arrest. It promotes β-catenin degradation via a p53/Siah1-dependent and GSK3β-independent proteasomal pathway. PW1 is required for both TNF- and DNA damage/p53-mediated differentiation in myoblasts. It promotes follicle growth in PW1 reporter-expressing epidermal cells that are capable of self-renewal following injury. While PW1 is found in certain stem/progenitor cells, it is also located in a variety of adult tissues, including intestine, testis, ovary, uterus, central nervous system, brain, bone, skeletal muscle, and skin. It is also located in placenta tissue and in glial cells and astrocytes. View All» Species Reactivity:

• Human

• Chimpanzee
  View All» Species Reactivity Note: Demonstrated to react with Human. Predicted to react with Chimpanzee based on 100% sequence homology. View All» Control: Human placenta tissue View All» Quality Assurance: Evaluated by Immunohistochemistry in human placenta tissue.Immunohistochemistry Analysis: A 1:200 dilution of this antibody detected Pw1/Peg3 in human placenta tissue. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9GZU2 View All» Entrez Gene Number: NP_006201 View All» Gene Symbol: PEG3 View All» Alternate Names:
  • Paternally-expressed gene 3 protein

  • Zinc finger and SCAN domain-containing protein 24
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunohistochemistry (Paraffin) View All» Entrez Gene Summary: In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms. View All» UniProt Summary: FUNCTION: Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B. Possesses a tumor suppressing activity in glioma cells.SUBUNIT STRUCTURE: Homodimer. Interacts with SIAH1A and SIAH2. Interacts with TRAF2.SUBCELLULAR LOCATION: Nucleus. Cytoplasm.TISSUE SPECIFICITY: Brain, glial cells, astrocytes, embryo, placenta, testis, ovary and uterus. In the placenta it is found in the layer of villous cytotrophoblast cells while in the ovary it is found in the cells of the ovarian stroma including the thecal layers around the follicles. Expression is highly repressed in glioma cell lines. View All» Product Name: Anti-Pw1/Peg3 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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