货号：ABD50

品牌：Merck Millipore

规格：

目录价：￥4025.00

市场价格：￥3421.25

会员价格：￥3220.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-BMPR-1B Antibody | ABD50 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes BMPR-1B at the cytoplasmic domain. View All» Molecular Weight: ~48 kDa observed. The calculated molecular weight is 56 kDa; however, BMPR-1B has been shown as a ~45 kDa band in western blots. (Paradis, F., et al. (2009). Reproduction. 138:115–129.) View All» Epitope: Cytoplasmic domain View All» Immunogen: KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human BMPR-1B. View All» Background Information: BMPR-1B (bone morphogenic protein receptor type 1B) is a serine-threonine kinase receptor expressed in granulosa cells. Increased expression of BMPR-1B has been linked to increased ovulation rates in some mammals. BMPR-1B has recently been associated with astrogliosis after a spinal cord injury. BMPR-1A and BMPR-1B work together to suppress ovarian tumorigenesis. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Rhesus Macaque
  View All» Species Reactivity Note: Demonstrated to react with Human, Mouse, and Rat. Predicted to react with Rhesus Macaque based on 100% sequence homology. View All» Application Notes: Western Blot Analysis: 0.5 - 1 µg/mL from a representative lot detected BMPR-1B on 10 µg of mouse ovary tissue and L6 cell lysates. View All» Control: Human ovary tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human ovary tissue lysate.Western Blot Analysis: 1 µg/mL of this antibody detected BMPR-1B on 10 µg of human ovary tissue lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O00238 View All» Entrez Gene Number: NP_001194 View All» Gene Symbol: BMPR1B View All» Alternate Names:
  • Bone morphogenetic protein receptor type-1B

  • BMP type-1B receptor

  • BMPR-1B

  • CDw293
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5.CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.COFACTOR: Magnesium or manganese (By similarity).SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. INVOLVEMENT IN DISEASE: Defects in BMPR1B are the cause of acromesomelic chondrodysplasia with genital anomalies (AMDGA) [MIM:609441]. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs, and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers). Defects in BMPR1B are a cause of brachydactyly type A2 (BDA2) [MIM:112600]. Brachydactylies (BDs) are a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. They have been classified on an anatomic and genetic basis into five groups, A to E, including three subgroups (A1 to A3) that usually manifest as autosomal dominant traits. BDA2 was described first in a large Norwegian kindred. BDA2 is caused by mutations in BMPR1B gene and studies demonstrate that these mutations function as dominant negatives in vitro and in vivo. SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.Contains 1 GS domain.Contains 1 protein kinase domain. View All» Product Name: Anti-BMPR-1B View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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