货号：ABD66

品牌：Merck Millipore

规格：100Ug

目录价：￥4626.00

市场价格：￥3932.10

会员价格：￥3700.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Adipose Triglyceride Lipase (PNPLA2) Antibody | ABD66 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Adipose Triglyceride Lipase at the lumenal domain. View All» Molecular Weight: ~53kDa observed. Uniprot describes 2 isoforms produced by alternative splicing with molecular weights of 55 kDa and 19 kDa. View All» Epitope: Lumenal domain View All» Immunogen: KLH-conjugated linear peptide corresponding to the lumenal domain of human Adipose Triglyceride Lipase. View All» Background Information: Adipose Triglyceride Lipase, also known as PNPLA2, is a member of the PNPLA family of proteins. It specifically hydrolyses triglycerides and may be involved in the degradation of adiposomes. This protein is expressed in adipose tissue, heart, skeletal muscle, and portions of the gastrointestinal tract. Adipose Triglyceride Lipase has acylglycerol transacylase activity and may act coordinately with LIPE/HLS within the lipolytic cascade. Mutations in Adipose Triglyceride Lipase have been associated with neutral lipid storage disease with myopathy. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Bovine
  View All» Species Reactivity Note: Demonstrated to react with Human, Mouse, and Rat. Predicted to react with Bovine based on 100% sequence homology. View All» Application Notes: Immunohistochemistry Analysis: A 1:300 dilution from a representative lot detected Adipose Triglyceride Lipase in human colon, rat skeletal muscle, and rat retina tissues. View All» Control: NIH/3T3 L1 adipocytes View All» Quality Assurance: Evaluated by Western Blot in NIH/3T3 L1 adipocytes.Western Blot Analysis: 1 µg/mL of this antibody detected Adipose Triglyceride Lipase on 10 µg of NIH/3T3 L1 adipocytes. View All» Purification Method: Protein A purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q96AD5 View All» Entrez Gene Number: NP_065109 View All» Gene Symbol:
  • PNPLA2

  • ATGL
    View All» Alternate Names:
    • Patatin-like phospholipase domain-containing protein 2

    • Adipose triglyceride lipase

    • Calcium-independent phospholipase A2

    • Desnutrin

    • IPLA2-zeta

    • Pigment epithelium-derived factor

    • TTS2.2

    • Transport-secretion protein 2

    • TTS2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)
        View All» Entrez Gene Summary: This gene encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Mutations in this gene are associated with neutral lipid storage disease with myopathy. [provided by RefSeq, Jul 2010]. View All» UniProt Summary: FUNCTION: Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes. May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion. CATALYTIC ACTIVITY: Triacylglycerol + H2O = diacylglycerol + a carboxylate.ENZYME REGULATION: Inhibited by BEL ((E)-6-(bromomethylene)-3-(1-naphthalenyl)-2H-tetrahydropyran-2-one), a suicide substrate inhibitor. No differences in enzymatic activity that uses (1,2-dilinoleoyl)-phosphatidylcholine as substrate was detected in the presence or absence of ATP. Activated by ABHD5 and SERPINF1. PATHWAY: Glycerolipid metabolism; triacylglycerol degradation.SUBUNIT STRUCTURE: Interacts with ABHD5; this association stimulates PNPLA2 triglyceride hydrolase activity (By similarity). Interacts with SERPINF1; interacts at one site of interaction. Despite a colocalization in lipid droplets, it probably does not interact with PLIN (By similarity). SUBCELLULAR LOCATION: Lipid droplet. Cell membrane; Single-pass type II membrane protein TISSUE SPECIFICITY: Highest expression in adipose tissue. Also detected in heart, skeletal muscle, and portions of the gastrointestinal tract. Detected in normal retina and retinoblastoma cells. Detected in retinal pigment epithelium and, at lower intensity, in the inner segments of photoreceptors and in the ganglion cell layer of the neural retina (at protein level). DEVELOPMENTAL STAGE: Induced during differentiation of primary preadipocytes to adipocytes. Expression increased from fetal to adult in retinal pigment epithelium. POLYMORPHISM: Genetic variations in PNPLA2 may be associated with plasma free fatty acids, triglycerides levels, and fasting glucose concentrations.INVOLVEMENT IN DISEASE: Note=Genetic variations in PNPLA2 may be associated with risk of diabetes mellitus type 2.Defects in PNPLA2 are the cause of neutral lipid storage disease with myopathy (NLSDM) [MIM:610717]; also known as neutral lipid storage disease without ichthyosis. NSLDM is a neutral lipid storage disorder (NLSD) with myopathy but without ichthyosis. NLSDs are characterized by the presence of triglyceride-containing cytoplasmic droplets in leukocytes and in other tissues, including bone marrow, skin, and muscle. Individuals with NLSDM did not show obesity, in spite of a defect in triglyceride degradation in fibroblasts and in marked triglyceride storage in liver, muscles, and other visceral cells. SEQUENCE SIMILARITIES: Contains 1 patatin domain.BIOPHYSICOCHEMICAL PROPERTIES: pH dependence:Optimum pH is 7.5 with (1,2-dilinoleoyl)-phosphatidylcholine as substrate. SEQUENCE CAUTION: The sequence AAP34448.1 differs from that shown. Reason: Frameshift at position 501. The sequence CAC01131.1 differs from that shown. Reason: Erroneous initiation. The sequence CAC01132.1 differs from that shown. Reason: Erroneous initiation. View All» Product Name: Anti-Adipose Triglyceride Lipase (PNPLA2) View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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