货号：ABE114

品牌：Merck Millipore

规格：100Ug

目录价：￥4746.00

市场价格：￥4034.10

会员价格：￥3796.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PRDM5 Antibody | ABE114 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~75 kDa observed. Three isoforms at 73, 70, and 13 kDa have been described. Uncharacterized bands between 13 and 73 kDa may be observed in some lysates. View All» Immunogen: Linear peptide corresponding to human PRDM5. View All» Background Information: PRDM5 is a member of the PR-domain containing family of tumor suppressors. PRDM5 activates histone methyltransferase G9a and class I histone deacetylases to regulate transcription. PRDM5 typically functions as a transcriptional repressor but can also be an activator for endogenous target genes. PRDM5 has often been found to be silenced in human breast, ovarian and liver cancers and and is a candidate biomarker for certain cancers, such as gastrointestinal cancer. Additional studies have also linked the loss of PRDM5 function to the development and pathogenesis of cervical cancer. View All» Species Reactivity:

• Human

• Chimpanzee
  View All» Species Reactivity Note: Demonstrated to react with Human. Predicted to react with Chimpanzee based on 100% sequence homology. View All» Application Notes: Western Blot Analysis:1 µg/mL from a representative lot detected PRDM5 on 10 µg of HeLa cell lysate and HeLa nuclear extract. View All» Control: PC3 cell lysate View All» Quality Assurance: Evaluated by Western Blot in PC3 cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected PRDM5 on 10 µg of PC3 cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9NQX1 View All» Entrez Gene Number: NP_061169 View All» Gene Symbol:
  • PRDM5

  • PFM2
    View All» Alternate Names:
    • PR domain zinc finger protein 5

    • PR domain-containing protein 5
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. SUBUNIT STRUCTURE: Interacts with EHMT2/G9A, GFI1 and HDAC1.SUBCELLULAR LOCATION: Nucleus SEQUENCE SIMILARITIES: Contains 16 C2H2-type zinc fingers.Contains 1 SET domain. View All» Product Name: Anti-PRDM5 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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