货号：ABE118

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-HOX-A11 Antibody | ABE118 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~30 kDa observed. An uncharacterized band appears at ~51 kDa. View All» Immunogen: KLH-conjugated linear peptide corresponding to human HOX-A11. View All» Isotype: IgG View All» Background Information: Homeobox protein Hox-A11 (HOX-A11) is a nuclear, sequence-specific transcription factor belonging to the Abd-B homeobox family and containing a single homeobox DNA-binding domain. HOX-A11 expression along the anterior-posterior axis of cells provides specific, positional identities for the purpose of developmental regulation. It is a required component for uterine and cervical development as it mediates both proliferation and stromal cell death. HOX-A11 is necessary for female fertility and normal implantation. It is also involved in regulating kidney branching. Defects in expression are considered causal to radioulnar synostosis with amegakaryocytic thrombocytopenia. View All» Species Reactivity:

• Mouse

• Human
  View All» Species Reactivity Note: Demonstrated to react with mouse.Predicted to react with human based on 100% sequence homology. View All» Control: Mouse lymph node tissue lysate View All» Quality Assurance: Evaluated by Western Blot in mouse lymph node tissue lysate.Western Blot Analysis: A 1:1,000 dilution of this antibody detected HOX-A11 in 10 µg of mouse lymph node tissue lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit polyclonal serum containing 0.5% sodium azide. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: P31270 View All» Entrez Gene Number: NP_005514 View All» Gene Symbol:
  • HOXA11

  • HOX1

  • HOX1I
    View All» Alternate Names:
    • homeobox A11

    • homeo box 1I

    • homeobox protein Hox-1Il

    • homeobox protein HOXA11

    • homeo box A11

    • homeobox protein Hox-A11
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.SUBCELLULAR LOCATION: Nucleus. INVOLVEMENT IN DISEASE: Defects in HOXA11 are the cause of radioulnar synostosis with amegakaryocytic thrombocytopenia [MIM:605432]. The syndrome consists of an unusual association of bone marrow failure and skeletal defects. Patients have the same skeletal defects, the proximal fusion of the radius and ulna, resulting in extremely limited pronation and supination of the forearm. Some patients have also symptomatic thrombocytopenia, with bruising and bleeding problems since birth, necessitating correction by bone marrow or umbilical-cord stem-cell transplantation. SEQUENCE SIMILARITIES: Belongs to the Abd-B homeobox family.Contains 1 homeobox DNA-binding domain. View All» Product Name: Anti-HOX-A11 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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