货号：ABE131

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SIX1 Antibody | ABE131 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~ 29 kDa observed. Uncharacterized band at ~12 kDa has been reported in some lysates. View All» Immunogen: KLH-conjugated linear peptide corresponding to human SIX1. View All» Isotype: IgG View All» Background Information: Homeobox protein SIX1 is a member of the SIX/SINE oculis homeobox family of proteins and contains a single homeobox DNA-binding domain. SIX1 is believed to participate in the development of limb ligaments and tendons. It is also a crucial component for patterning in early organogenesis. Overexpression of the homeoptrotein has been shown to induce tumorigenesis through the direct transcriptional activation of cyclin A1. SIX1 presence has been reported in breast and ovarian carcinomas. Expression of SIX1 is specific to skeletal muscle. Defects in SIX1 expression are causal to branchiootic syndrome type 3 (BOS3) and deafness autosomal dominant type 23 (DFNA23). View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Control: Human uterus tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human uterus tissue lysate.Western Blot Analysis: 1:1,000 dilution of this antibody detected SIX1 on 10 µg of human uterus tissue lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in PBS containing 0.5% Azide, 0.01% BSA and 0.001% Thimerosal. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q15475 View All» Entrez Gene Number: NP_005973 View All» Gene Symbol:

• SIX1

• BOS3

• DFNA23

• TIP39
  View All» Alternate Names:
  • SIX homeobox 1

  • sine oculis homeobox homolog 1 (Drosophila)

  • Sine oculis homeobox homolog 1

  • deafness, autosomal dominant 23

  • homeobox protein SIX1

  • sine oculis homeobox (Drosophila) homolog 1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3). [provided by RefSeq]. View All» UniProt Summary: FUNCTION: May be involved in limb tendon and ligament development (By similarity).SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICTY: Specifically expressed in skeletal muscle.INVOLVEMENT IN DISEASE: Defects in SIX1 are the cause of deafness autosomal dominant type 23 (DFNA23) [MIM:605192]. A form of non-syndromic deafness characterized by prelingual, bilateral, symmetric hearing loss with a conductive component present in some but not all patients. Defects in SIX1 are the cause of branchiootic syndrome type 3 (BOS3) [MIM:608389]. Urinary tract malformations constitute the most frequent cause of chronic renal failure in the first two decades of life. Branchio-oto-renal syndrome (BOR) is an autosomal dominant developmental disorder of kidney and urinary tract malformations with hearing loss. The major feature of BOR is hearing loss (93% of patients), which can be conductive, sensorineural, or both and varies in age of onset. SEQUENCE SIMILARITIES: Belongs to the SIX/Sine oculis homeobox family.Contains 1 homeobox DNA-binding domain. View All» Product Name: Anti-SIX1 View All» Concentration: 0.14 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
    © 金山科研平台是专业的授权总代理区域代理经销平台。
    © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
    © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
    © 本文地址：https://www.16ao.com/thread-158908.htm
    © Merck Millipore代理ABE131 Anti-SIX1;已停产，产品报价联系微信jinshanbio