货号：ABE159

品牌：Merck Millipore

规格：

目录价：￥4633.00

市场价格：￥3938.05

会员价格：￥3706.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-acetyl-Histone H2B (Lys120) Antibody | ABE159 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the C-terminus of Histone H2B acetylated at Lys120. View All» Molecular Weight: ~16 kDa observed View All» Epitope: C-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to the C-terminus of human Histone H2B acetylated at Lys120. View All» Background Information: Histone H2B is one of four histones that form a core octameric structure required for the packaging of DNA into nucleosomes, the most basic level of chromatin arrangement. Histones undergo a number of post-translational modifications (PTM) at their N- and C-terminal tails which can influence chromatin structure and stability; and consequently, transcription, and DNA replication and repair. Acetylation is a reversible PTM that involves the transfer of acetyl groups to N-terminal lysine residues by a family of histone acetyltransferase enzymes, including GNAT, Gcn5, and p300/CBP. Histone acetylation reduces the electrostatic attractions between DNA and histones, which destabilizes chromatin structure and provide transcriptional complexes, for example, with access to DNA, potentially resulting in increased gene transcription. Lysine 120 of H2B (H2BK120) undergoes acetylation (by p300/CBP) and ubiquitination. Acetylation occurs first and is required for subsequent mono-ubiquitination. H2BK120 may function as a marker of “pre-active” chromatin, and is part of a complex regulatory system involving multiple histone modifications. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Human, Mouse, and Rat. View All» Application Notes: Immunoprecipitation Analysis: 10 mg from a representative lot immunoprecipitated acetyl-Histone H2B (Lys120) in 1 mg of sodium butyrate treated HeLa acid extract.Dot Blot (Specificity) Analysis: A representative lot detected acetyl-Histone H2B (Lys120) peptides, but not unacetylated-histone H2B (Lys120) peptides or other peptides corresponding to modified histones. View All» Control: Untreated and sodium butyrate treated HeLa acid extract and recombinant Histone H2B View All» Quality Assurance: Evaluated by Western Blot in untreated and sodium butyrate treated HeLa acid extract and in recombinant Histone H2B.Western Blot Analysis: 0.1 mg/mL of this antibody detected acetyl-Histone H2B (Lys120) in 10 ng of untreated and sodium butyrate treated HeLa acid extract. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P58876 View All» Entrez Gene Number: NP_066407 View All» Gene Symbol:
  • HIST1H2BD

  • H2BFB

  • HIRIP2
    View All» Alternate Names:
    • Histone H2B type 1-D

    • HIRA-interacting protein 2

    • Histone H2B.1 B

    • Histone H2B.b

    • H2B/b
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunoprecipitation

      • Dot Blot
        View All» Product Name: Anti-acetyl-Histone H2B (Lys120) View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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