货号：ABE16

品牌：Merck Millipore

规格：

目录价：￥3849.00

市场价格：￥3271.65

会员价格：￥3079.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-HDAC10 Antibody | ABE16 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes HDAC10 at the N-terminus. View All» Molecular Weight: ~75 kDa observed View All» Epitope: N-terminus View All» Immunogen: GST-tagged recombinant protein corresponding to the N-terminus of human HDAC10. View All» Background Information: Histone deacetylase 10 (HDAC10) is a class II histone deacetylase, based on homology to HDAC6, that may be important in transcription regulation. HDAC10 is comprised of an amino-terminal catalytic domain and a carboxy pseudo-repeat. HDAC10 is found in the nucleus, where it is thought to function as a transcriptional modulator, and in the cytoplasm, where function is still unknown. Class II HDAC’s have been associated with breast cancer progression and estrogen dependence. Additional studies have demonstrated that HDAC10 is an important regulator of melanogenesis and that levels of cellular melanin correlate with HDAC expression. View All» Species Reactivity:

• Human

• Mouse

• Chimpanzee
  View All» Species Reactivity Note: Demonstrated to react with Human and Mouse. Predicted to react with Chimpanzee based on 100% sequence homology. . View All» Application Notes: Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected HDAC10 in NIH/3T3, A431, and HeLa cells. View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: 2.5 µg/mL of this antibody detected HDAC10 on 10 µg of HeLa cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q969S8 View All» Entrez Gene Number: NP_001152758 View All» Gene Symbol:
  • HDAC10

  • HD10
    View All» Alternate Names:
    • histone deacetylase

    • HDAC 10
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry
        View All» Entrez Gene Summary: Acetylation of histone core particles modulates chromatin structure and gene expression. The opposing enzymatic activities of histone acetyltransferases and histone deacetylases, such as HDAC10, determine the acetylation status of histone tails (Kao et al., 2002 [PubMed 11677242]).[supplied by OMIM]. View All» UniProt Summary: FUNCTION: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.CATALYTIC ACTIVITY: Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.SUBUNIT STRUCTURE: Interacts with HDAC2, HDAC3 and NCOR2. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note: Excluded from the nucleoli.TISUE SPECIFICTY: Ubiquitous. High expression in liver, spleen, pancreas and kidney.SEQUENCE SIMILARITIES: Belongs to the histone deacetylase family. HD type 2 subfamily. View All» Product Name: Anti-HDAC10 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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