货号：ABE179

品牌：Merck Millipore

规格：

目录价：￥3789.00

市场价格：￥3220.65

会员价格：￥3031.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho LSF (Ser291) Antibody | ABE179 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes LSF phosphorylated at Ser291. View All» Molecular Weight: ~60 kDa observed. An uncharacterized band at ~155 kDa maybe observed in some lysates. View All» Epitope: Phosphorylated Ser291 View All» Immunogen: KLH-conjugated linear peptide corresponding to human LSF phosphorylated at Ser291. View All» Modifications: Phosphorylation View All» Background Information: Transcription factor LSF, also known as alpha-globin transcription factor CP2, binds to DNA as a dimer and directly interacts with the alpha-globin promoter to activate transcription. Studies suggest transcription factor LSF regulates erythroid gene expression and plays a key role in the transcriptional switch of globin gene promoters. This protein has also been demonstrated to bind to a number of different cellular and viral promoters such as fibrinogen, alpha-globin, SV40 and HIV-1. View All» Species Reactivity:

• Mouse

• Human
  View All» Species Reactivity Note: Demonstrated to react with Mouse. Predicted to react with Human based on immunogen design. View All» Control: Calyculin A/okadaic acid untreated and treated NIH/3T3 cell lysates View All» Quality Assurance: Evaluated by Western Blot in Calyculin A/okadaic acid untreated and treated NIH/3T3 cell lysates.Western Blot Analysis: 1:500 dilution of this antibody detected LSF on 10 µg of Calyculin A/okadaic acid untreated and treated NIH/3T3 cell lysates. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q12800 View All» Entrez Gene Number: NP_005644 View All» Gene Symbol:
  • LSF

  • TFCP2

  • SEF
    View All» Alternate Names:
    • Alpha-globin transcription factor CP2

    • SAA3 enhancer factor

    • Transcription factor LSF
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. The encoded protein regulates erythroid gene expression, plays a role in the transcriptional switch of globin gene promoters, and it activates many other cellular and viral gene promoters. The gene product interacts with certain inflammatory response factors, and polymorphisms of this gene may be involved in the pathogenesis of Alzheimer's disease. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter. SUBUNIT STRUCTURE: Binds to DNA as a dimer, isoform 3 does not bind to DNA or affect the binding of isoform 1 to DNA. Interacts with UBP1 and PIAS1, and is probably part of a complex containing TFCP2, UBP1 and PIAS1 (By similarity). Component of the SSP (stage selector protein) complex, which appears to be a heteromer of TFCP2 and 2 copies of NFE4. SUBCELLULAR LOCATION: Nucleus TISSUE SPECIFICTY: Ubiquitous. Expressed in brain, ovary, kidney, thymus, spleen, liver, adrenal, heart and lung (at protein level). DEVELOPMENTAL STAGE: Expressed in fetal erythroid tissue. MISCELLANEOUS: In Ref.2 authors noted that a 10-fold molar excess of isoform 3 over isoform 1 inhibited DNA-binding.SEQUENCE SIMILARITIES: Belongs to the grh/CP2 family. CP2 subfamily. View All» Product Name: Anti-phospho LSF (Ser291) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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