货号：ABE195

品牌：Merck Millipore

规格：100UL

目录价：￥4493.00

市场价格：￥3819.05

会员价格：￥3594.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-JMJD1A Antibody | ABE195 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~147 kDa observed View All» Immunogen: GST-tagged recombinant protein corresponding to human JMJD1A. View All» Background Information: JMJD1A (jumonji domain-containing 1a), also known as JHDM2A is member of the jumonji (jmj) domain containing gene family of proteins. This protein functions as a histone demethylase that demethylates mono and dimethyl lysine 9 of histone H3. Consequently, this protein plays a role in the regulation of chromatin structure and influences transcriptional activation and suppression. Loss of function of JMJD1A leads to embryonic stem cell differentiation. JMJD1A has also been implicated in smooth muscle cell-specific transcription, hypoxic gene expression and tumor growth. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Control: HeLa nuclear extract View All» Quality Assurance: Evaluated by Western Blot in HeLa nuclear extract.Western Blot Analysis: 1:1,000 dilution of this antibody detected JMJD1A on 10 µg of HeLa nuclear extract. View All» Purification Method: Unpurified View All» Presentation: Rabbit polyclonal serum containing 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q9Y4C1 View All» Entrez Gene Number: NP_060903.2 View All» Gene Symbol:

• JHDM2A

• TSGA

• JHMD2A

• JMJD1A

• JMJD1

• KDM3A
  View All» Alternate Names:
  • JMJD

  • lysine (K)-specific demethylase 3A

  • testis-specific protein A

  • jumonji domain containing 1A

  • jumonji C domain-containing histone demethylase 2A

  • jumonji domain containing 1

  • Jumonji domain-containing protein 1A

  • JmjC domain-containing histone demethylation protein 2A

  • lysine-specific demethylase 3A JMJD1A

  • JMJD1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1. COFACTOR: Binds 1 Fe2+ ion per subunit. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note: Nuclear in round spermatids. When spermatids start to elongate, localizes to the cytoplasm where it forms distinct foci which disappear in mature spermatozoa (By similarity).DOMAIN: The JmjC domain and the C6-type zinc-finger are required for the demethylation activity. Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors (By similarity). SEQUENCE SIMILARITIES: Belongs to the JHDM2 histone demethylase family.Contains 1 JmjC domain.SEQUENCE CAUTION: The sequence BAA34462.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. View All» Product Name: Anti-JMJD1A View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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