货号：ABE223

品牌：Merck Millipore

规格：100UL

目录价：￥5141.00

市场价格：￥4369.85

会员价格：￥4112.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-acetyl Histone H3 (Lys4) Antibody | ABE223 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Histone H3 acetylated at Lys4. View All» Molecular Weight: ~17 kDa observed. An uncharacterized band appears at ~37 kDa in some lysates. View All» Epitope: Acetylated Lys4 View All» Immunogen: KLH-conjugated linear peptide corresponding to human Histone H3 acetylated at Lys4. View All» Background Information: Histones are nuclear proteins that form octameric structures which bind DNA to form units of chromatin called nucleosomes. The family of histones—H2A, H2B, H3, and H4—are key players in gene regulation. They undergo a number of post-translational modifications (PTM) in response to various stimuli. Acetylation is a reversible PTM that involves the transfer of acetyl groups to N-terminal lysine (K) residues by a family of histone acetyltransferase enzymes, including GNAT, Gcn5, and p300/CBP. Histone acetylation reduces the electrostatic attractions between DNA and histones, which destabilizes chromatin structure and provide chromatin remodeling and transcriptional complexes, with access to DNA, potentially resulting in increased gene transcription. In fission yeast, H3K4 is acetylated by Gcn5 and Rtt109. H3K4Ac is found at the promoters of active genes. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Application Notes: Dot Blot Specificity Analysis: Unmodified and various modified Histone peptides (see Table) were probed with Anti-acetyl-Histone H3 (Lys4).Immunoprecipitation Analysis: 10 μg from a representative lot immunoprecipitated acetyl Histone H3 (Lys4) from sodium butyrate treated HeLa acid extract.Western Blotting Analysis:Representative lot data.Evaluated by Western Blotting in sodium butyrate treated HeLa acid extract.Cat. No. ABE223, Anti-acetyl Histone H3 (Lys4) (1:1000 dilution). detected Histone H3 acetylated on Lys4 in 10 µg of sodium butyrate treated HeLa acid extract. Proteins were visualized using a Donkey Anti-Rabbit IgG secondary antibody conjugated to HRP and a chemiluminescence detection system.Arrow indicates acetyl Histone H3 (Lys4) (~17 kDa). View All» Control: Sodium butyrate treated HeLa acid extract View All» Quality Assurance: Evaluated by Western Blot in sodium butyrate treated HeLa acid extract.Western Blot Analysis: A 1:1,000 dilution of this antibody detected Histone H3 acetylated on Lys4 in 10 µg of sodium butyrate treated HeLa acid extract. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P68431 View All» Entrez Gene Number: NP_003520 View All» Gene Symbol:
  • HIST1H3A

  • H3FA

  • HIST1H3B

  • H3FL

  • HIST1H3C

  • H3FC

  • HIST1H3D

  • H3FB

  • HIST1H3E

  • H3FD

  • HIST1H3F

  • H3FI

  • HIST1H3G

  • H3FH

  • HIST1H3H

  • H3FK

  • HIST1H3I

  • H3FF

  • HIST1H3J

  • H3FJ
    View All» Alternate Names:
    • Histone H3.1

    • Histone H3/a

    • Histone H3/b

    • Histone H3/c

    • Histone H3/d

    • Histone H3/f

    • Histone H3/h

    • Histone H3/I

    • Histone H3/j

    • Histone H3/k

    • Histone H3/l

    • h3K4Ac
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunoprecipitation

      • Dot Blot
        View All» Product Name: Anti-acetyl Histone H3 (Lys4) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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