货号：ABE236

品牌：Merck Millipore

规格：

目录价：￥3393.00

市场价格：￥2884.05

会员价格：￥2714.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-CDK5RAP2 Antibody | ABE236 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes CDK5RAP2 at the N-terminus. View All» Molecular Weight: ~250 kDa observed View All» Epitope: N-terminus View All» Immunogen: GST-tagged recombinant protein corresponding to the N-terminus of mouse CDK5RAP2. View All» Background Information: CDK5RAP2 (CDK5 regulatory subunit-associated protein 2) potentially regulates CDK5 activity by interacting with CDK5R1. CDK5 is a brain specific cyclin-dependent kinase important to mammalian brain development. Studies implicate CDK5RAP2 involvement in centrosome directed production of microtubules and mitotic spindle formation during neuronal cell division. Mutations in CDK5RAP2 have been linked to the developmental disorder autosomal recessive primary microcephaly. View All» Species Reactivity:

• Mouse

• Human

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Mouse, Human, and Rat. View All» Application Notes: Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected CDK5RAP2 in NIH/3T3 and A431 cells.Immunohistochemistry Analysis: This antibody was used by an independent laboratory in IHC (see 2. Barrera, J.A., et al. (2010). Dev Cell. 18(6):913-926.) View All» Control: NIH/3T3 cell lysate View All» Quality Assurance: Evaluated by Western Blot in NIH/3T3 cell lysate.Western Blot Analysis: A 1:500 dilution of this antibody detected CDK5RAP2 on 10 µg of NIH/3T3 cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q8K389 View All» Entrez Gene Number: NP_666102 View All» Gene Symbol: Cdk5rap2 View All» Alternate Names:
  • CDK5 regulatory subunit-associated protein 2

  • CDK5 activator-binding protein C48
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry

    • Immunohistochemistry
      View All» UniProt Summary: FUNCTION: Potential regulator of CDK5 activity via its interaction with CDK5R1. Involved in regulation of mitotic spindle orientation By similarity. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation and brain development. SUBUNIT STRUCTURE: Interacts with CDK5R1 (p35 form). CDK5RAP1, CDK5RAP2 and CDK5RAP3 show competitive binding to CDK5R1. Probably forms a complex with CDK5R1 and CDK5 (By similarity). Interacts with PCNT; the interaction is leading to centrosomal localization of CDK5RAP2 and PCNT. Interacts with AKAP9; the interaction is leading to Golgi localization of CDK5RAP2 and AKAP9 (By similarity). Interacts with TUBG1; the interaction is leading to centrosomal localization of CDK5RAP2 and TUBG1. Interacts with TUBGCP3 (By similarity). Interacts with CALM1 (By similarity). Interacts with CDC20 (By similarity). According to Ref.4, CDK5RAP2 does not interact with MAPRE1. SUBCELLULAR LOCATION: Cytoplasm › cytoskeleton › centrosome. Golgi apparatus (By similarity). Cytoplasm (By similarity).TISSUE SPECIFICITY: Expressed in testis, thymus, heart and brain. Ref.6DEVELOPMENTAL STAGE: Expressed from E9.5 in the developing cortex. Its expression peaks during periods of active neurogenesis. PTM: Phosphorylated in vitro by CDK5 (By similarity).SEQUENCE CAUTION: The sequence BAC98221.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. View All» Product Name: Anti-CDK5RAP2 View All» Concentration: 0.1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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