货号：ABE240

品牌：Merck Millipore

规格：

目录价：￥4264.00

市场价格：￥3624.40

会员价格：￥3411.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MLL-C Antibody | ABE240 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~180 kDa observed. Multiple uncharacterized bands typically below 180 kDa have been observed in some lysates. View All» Epitope: 0 View All» Immunogen: GST-tagged recombinant protein corresponding to the expressed protein of human MLL-C. View All» Background Information: MLL is a histone methyltransferase and chromatin modifier that plays a role in hematopoiesis. This protein is implicated in HOX gene regulation in early embryogenesis and in the regulation of non-HOX genes p27 (Kip1) and p18 (lnk4C). It is part of a catalytic subunit of the MLL1/MLL complex, which mediates the acetylation of Lys-16 of histone H4 (H4K16ac) and the methylation of Lys-4 of histone H3 (H3K4me). It is reported that MLL interacts directly with the polymerase associated factor complex (PAFc) through sequences flanking the CxxC domain. Subsequently, PAFc interacts with RNA polymerase II and thereby stimulates posttranslational histone modifications. Taspase 1, catalyzes MLL into MLL-C and MLL-N, both of which reassociate and later reassemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Mutations in the MLL gene are linked to certain acute myeloid and lymphoid leukemias. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with Human and Mouse. View All» Application Notes: Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected MLL-C in NIH/3T3, A431, and HeLa cells.Chromatin Immunoprecipitation Analysis: A representative lot from an independent laboratory detected MLL-C in HeLa cells. (Milne, T.A., et al. (2005). Proc Natl Acad Sci USA. 102(3):749-754.) View All» Control: HeLa nuclear extract View All» Quality Assurance: Evaluated by Western Blot in HeLa nuclear extract.Western Blot Analysis: A 1:1,000 dilution of this antibody detected the expressed protein of human MLL-C in 10 µg of HeLa nuclear extract. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q03164 View All» Entrez Gene Number: NP_001184033 View All» Gene Symbol:
  • MLL

  • ALL1

  • CXXC7

  • HRX

  • HTRX

  • KMT2A

  • MLL1

  • TRX1
    View All» Alternate Names:
    • Histone-lysine N-methyltransferase MLL, ALL-1

    • CXXC-type zinc finger protein 7

    • Lysine N-methyltransferase 2A

    • KMT2A

    • Trithorax-like protein

    • Zinc finger protein HRX

    • MLL cleavage product C180

    • C-terminal cleavage product of 180 kDa

    • p180
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry
        View All» Entrez Gene Summary: This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants. View All» UniProt Summary: FUNCTION: Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis.CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SUBUNIT STRUCTURE: MLL cleavage product N320 heterodimerizes with MLL cleavage product C180 (via SET and FYRC domains). Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, HCFC2, WDR5, DPY30 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, IN80C, KIAA1267, LAS1L, MAX, MCRS1, MEN1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with WDR5; the interaction is direct. Interacts with MYST1/MOF; the interaction is direct. Interacts with SBF1 and PPP1R15A.SUBCELLULAR LOCATION: Nucleus. Localizes to a diffuse nuclear pattern when not associated with MLL cleavage product N320. View All» Product Name: Anti-MLL-C View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All» Applications: ChIP, WB, ICC View All»
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