货号：ABE25

品牌：Merck Millipore

规格：100Ug

目录价：￥4967.00

市场价格：￥4221.95

会员价格：￥3973.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-acetyl-c-Myc (Lys148) Antibody | ABE25 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes c-Myc acetylated at Lys148 in human and Lys149 in mouse. View All» Molecular Weight: ~58 kDa observed. Uniprot describes two isoforms at 49 and 51 kDa. Uncharacterized bands appear at ~13 and ~17 in some lysates. View All» Epitope: Acetylated Lys148 View All» Immunogen: KLH-conjugated linear peptide corresponding to human c-Myc acetylated at Lys148. View All» Background Information: c-Myc (bHLHe39) is a transcription factor that regulates the expression of multiple genes involved in apoptosis, cell growth, differentiation, and proliferation. Active c-Myc is coupled to the MAX protein via c-Myc’s C-terminal helix-loop-helix leucine zipper (bHLHLZ) domain. The c-Myc-MAX heterodimer also interacts with a number of other transcription-related proteins including TRRAP, p107 and Miz-1, and c-Myc-MAX may indirectly regulate histone acetylases involved in chromatin remodeling. c-Myc is itself acetylated on lysine 323 by GCN5, and on lysine 148 and 157 by p300/CBP. The significance of c-Myc acetylation is still under investigation; however, previous studies have suggested that HAT-dependent acetylation of c-Myc may regulate its turnover and stability. c-Myc may play a role in various cancers such as Burkitt’s lymphoma. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with Mouse and Human. Predicted to react with Rat, Bovine, Canine, Rhesus Macaque, Chimpanzee, Sheep, and Porcine based on 100% sequence homology. View All» Application Notes: Peptide Inhibition Assay Analysis: 2 µg/mL from a representative lot blocked acetyl-c-Myc (Lys148) in HEK293T cells co-transfected with wildtype c-Myc and P300.Peptide Inhibition Assay Analysis: A representative lot was used by an independent laboratory in HEK293T cells co-transfected with mouse wildtype c-Myc and P300. (Image courtesy of Dr. Ernest Martinez, Department of Biochemistry, University of California at Riverside.) View All» Control: Transfected HEK293 cell lysates View All» Quality Assurance: Evaluated by Western Blot in transfected HEK293 cell lysates.Western Blot Analysis: 0.1 µg/mL of this antibody detected c-Myc on 10 µg of transfected HEK293 cell lysates. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P01106 View All» Entrez Gene Number: NP_002458 View All» Gene Symbol:
  • MYC

  • BHLHE39
    View All» Alternate Names:
    • Myc proto-oncogene protein

    • Class E basic helix-loop-helix protein 39

    • HLHe39

    • Proto-oncogene c-Myc

    • Transcription factor p64

    • c-MYC
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Product Name: Anti-acetyl-c-Myc (Lys148) View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://www.16ao.com/thread-158988.htm
      © Merck Millipore代理ABE25 Anti-acetyl-c-Myc (Lys148) Antibody;store at +2℃ to +8℃，产品报价联系微信jinshanbio