货号：ABE252

品牌：Merck Millipore

规格：

目录价：￥3999.00

市场价格：￥3399.15

会员价格：￥3199.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Nanos homolog 2 Antibody | ABE252 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Nanos homolog 2 at the N-terminus. View All» Molecular Weight: ~37 kDa observed. The calculated molecular weight is 15 kDa, however Nanos homolog 2 has been shown as a ~37 kDa band in western blots (Kusz, K.M., et al. (2009). Molecular Human Reproduction. 15(3):165–171.) View All» Epitope: N-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to the N-terminus of human Nanos homolog 2. View All» Background Information: Nanos homolog 2 (NANOS2) is a zinc-finger RNA-binding protein that is expressed only in male gonads. Nanos homolog 2 opposes RA/Stra8 signaling that promotes meiosis and development of female germ cells. Nanos homolog 2 inhibits meiosis by actively suppressing the expression of mRNAs required for meiosis. Previous studies have shown that Nanos homolog 2 interacts with components of the CCR4-NOT complex and is involved in deadenylating and destabilizing mRNA molecules involved in meiosis. Furthermore, Nanos homolog 2 may mediate degradation of these RNA molecules by P-bodies. Hence, Nanos homolog 2 plays an important role in male sex determination. View All» Species Reactivity:

• Human

• Mouse

• Bovine

• Pig
  View All» Species Reactivity Note: Demonstrated to react in Human and Mouse. Predicted to react with Bovine and Porcine based on 100% sequence homology. Other homologies: Chinese Hamster, Marmoset, Giant Panda, and Rabbit (83% sequence homology). View All» Application Notes: Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected Nanos homolog 2 in rat seminiferous tubules. View All» Control: Human Testis Tissue Lysate View All» Quality Assurance: Evaluated by Western Blot in human testis tissue lysate.Western Blot Analysis: 1 µg/mL of this antibody detected Nanos homolog 2 on 10 µg of human testis tissue lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P60321 View All» Entrez Gene Number: Np_001025032 View All» Gene Symbol:
  • Nanos2

  • Nos2
    View All» Alternate Names:
    • Nanos Homolog 2

    • Nos-2
      View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry
        View All» UniProt Summary: FUNCTION: Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state (By similarity).SUBUNIT STRUCTURE: Interacts with CNOT1, CNOT3, CNOT6L, CNOT7 and CNOT9 (By similarity).SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm › P-body (By similarity). Cytoplasm › perinuclear region. Note: Localizes at P-bodies during gonocyte development (By similarity). More abundant in perinuclear region of the cytoplasm of the germ cells of the adult testis. TISSUE SPECIFICITY: Testis and ovary. Expression found in several spermatogenic stages: in cells on the periphery of the tubules which could correspond to spermatogonia, in spermatocytes and in round spermatids (at protein level). DEVELOPMENTAL STAGE: Fetal ovary and fetal testis. Present in all germ cells of seminiferous tubules of the 24-week fetus (at protein level). DOMAIN: The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein (By similarity).SEQUENCE SIMLARITIES: Belongs to the nanos family.Contains 1 nanos-type zinc finger. View All» Product Name: Anti-Nanos homolog 2 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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