货号：ABE269

品牌：Merck Millipore

规格：200UL

目录价：￥6127.00

市场价格：￥5207.95

会员价格：￥4901.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-acetyl-Histone H2B (Lys24) Antibody | ABE269 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Histone H2B acetylated at Lys24. View All» Molecular Weight: ~16 kDa observed View All» Epitope: Acetylated Lys24 View All» Immunogen: KLH-conjugated linear peptide corresponding to human Histone H2B acetylated at Lys24. View All» Background Information: Changes in chromatin structure play a large role in the regulation of transcription in eukaryotes (1). The nucleosome is the primary building block of chromatin, and is made up of four core histone proteins (H2A, H2B, H3 and H4) (2). Acetylation of core histones regulates gene expression (2). Histone H2B is primarily acetylated at lysines 5, 12, 15, and 20 (3). Ubiquitylation of Histone H2B at lysine 123 by Rad6 has been implicated in transcriptional activation and lysine methylation on histone H3 (4). Histone H2B phosphorylation at Ser10 (for yeast) and Ser14 (for mammalian cells) has been linked to regulation of apoptosis and meiosis (5). View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Human, Mouse, and Rat. View All» Application Notes: Immunoprecipitation Analysis: 10 μg from a representative lot immunoprecipitated acetyl-Histone H2B (Lys24) from HeLa acid extract. Dot Blot Specificity Analysis: Unmodified and various modified Histone peptides (see Table) were probed with Anti-acetyl-Histone H2B (Lys24) (1:500 dilution). View All» Control: Recombinant Histone H2B protein, and untreated and sodium butyrate treated HeLa acid extracts View All» Quality Assurance: Evaluated by Western Blot in recombinant Histone H2B protein, and untreated and sodium butyrate treated HeLa acid extracts.Western Blot Analysis: A 1:500 dilution of this antibody detected Histone H2B on 10 µg of recombinant Histone H2B protein, and untreated and sodium butyrate treated HeLa acid extracts. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q8N257 View All» Entrez Gene Number: NP_001019770 View All» Gene Symbol: HIST3H2BB View All» Alternate Names:
  • Histone H2B type 3-B

  • H2B type 12
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunoprecipitation

    • Dot Blot
      View All» Product Name: Anti-acetyl-Histone H2B (Lys24) View All» Concentration: 0.25 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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