货号：ABE28

品牌：Merck Millipore

规格：

目录价：￥4264.00

市场价格：￥3624.40

会员价格：￥3411.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-acetyl-MeCP2 (Lys464) Antibody | ABE28 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes MeCP2 acetylated at Lysine 464. View All» Molecular Weight: ~75 kDa observed. Two isoforms (A and B) with calculated molecular weights of ~52 kDa and 53 kDa are known to exist. This antibody should detect either isoform. View All» Epitope: Acetylated lysine 464 View All» Immunogen: KLH-conjugated linear peptide corresponding to mouse MeCP2 acetylated at Lys464. View All» Modifications: Acetylation View All» Background Information: DNA methyltransferases methylate the 5-position of cytosine in the context of CpG dinucleotides. DNA methylation is crucial for normal embryonic development, imprinting, and X chromosome inactivation. Methyl CpG binding proteins (MeCPs) specifically recognize methylated regions of DNA and repress transcription both directly and by association with known corepressor proteins which include members of the histone deacetylase protein families. View All» Species Reactivity:

• Mouse

• Human

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Mouse. Predicted to react with Human and Rat based on 100% sequence homology. View All» Application Notes: Western Blot Immunoprecipitation Analysis: A representative lot from an independent laboratory detected MeCP2 in 293 cell lysate derived from p300 co-transfected 293 cells. (Prof. Sassone-Corsi, Center for Epigenetics and Metabolism, University of California, Irvine.)Immunocytochemistry Analysis: A representative lot from an independent laboratory detected MeCP2 in mouse cortical neurons. (Prof. Sassone-Corsi, Center for Epigenetics and Metabolism, University of California, Irvine.)Alexa Fluor® is a registered trademark of Molecular Probes Inc. View All» Control: Non-acetylated and acetylated MeCP2 (Lys464) peptides. View All» Quality Assurance: Evaluated by Dot Blot using non-acetylated and acetylated MeCP2 (Lys464) peptides.Dot Blot Analysis: 1 µg/mL of this antibody detected MeCP2 using non-acetylated and acetylated MeCP2 (Lys464) peptides. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9Z2D6 View All» Entrez Gene Number: NP_034918 View All» Gene Symbol: Mecp2 View All» Alternate Names:
  • Methyl-CpG-binding protein 2

  • MeCp-2 protein

  • MeCp2
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Dot Blot

    • Western Blotting

    • Immunocytochemistry
      View All» Entrez Gene Summary: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. View All» UniProt Summary: FUNCTION: Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A.SUBUNIT STRUCTURE: Interacts with CDKL5. Interacts with FNBP3.SUBCELLULAR LOCATION: Nucleus. Note: Colocalized with methyl-CpG in the genome. View All» Product Name: Anti-acetyl-MeCP2 (Lys464) View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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