货号：ABE280

品牌：Merck Millipore

规格：100Ug

目录价：￥4592.00

市场价格：￥3903.20

会员价格：￥3673.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Ars2 Antibody | ABE280 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~120 kDa observed. Uncharacterized bands at ~78 kDa and 48 kDa may be observed in some lysates. View All» Immunogen: Linear peptide corresponding to human Ars2. View All» Background Information: As a component of the nuclear RNA cap-binding complex (CBC), Ars2 is known to play a critical role in miRNA biogenesis by stabilizing and linking capped primary miRNA transcripts with the primary miRNA processing complex containing DROSHA and DGGR8. Unlike other CBC components, Ars2 expression also plays an important role in cell proliferation. In particular, depletion of Ars2 is shown to reduce the levels of several miRNAs, such as miR-21, let-7, and miR-155, which are implicated in cellular transformation. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Human, Rat, and Mouse. View All» Application Notes: Immunoprecipitation Analysis: A representative lot from an independent laboratory detected Ars2 in IP. (Alex Achille, Department of Molecular Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA). View All» Control: HEK293 cell lysate View All» Quality Assurance: Evaluated by Western Blot in HEK293 cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected Ars2 in 10 µg of HEK293 cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9BXP5 View All» Entrez Gene Number: NP_001122324 View All» Gene Symbol:
  • SRRT

  • ARS2

  • ASR2
    View All» Alternate Names:
    • Serrate RNA effector molecule homolog

    • Arsenite-resistance protein 2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunoprecipitation
        View All» UniProt Summary: FUNCTION: Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity.SUBUNIT STRUCTURE: Interacts with NCBP1 and DROSHA. Interacts with CASP8AP2 and ERBB4.TISSUE SPECIFICITY: Ubiquitously expressed. View All» Product Name: Anti-Ars2 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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