货号：ABE285

品牌：Merck Millipore

规格：100Ug

目录价：￥4592.00

市场价格：￥3903.20

会员价格：￥3673.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Tristetraprolin Antibody | ABE285 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~40 kDa observed. Uniprot gives a calculated molecular weight of 34 kDa. An uncharacterized band appears at ~53 kDa in some lysates. View All» Immunogen: KLH-conjugated linear peptide corresponding to human Tristetraprolin. View All» Background Information: Tristetraprolin (TTP, Nup 475, TIS11, G0S24, or ZFP36) is a member of the CCCH tandem zinc finger protein family. It is a nuclear RNA-binding protein that functions as a trans-acting factor. It is involved in post-transcriptional regulation of cytokine genes, most notably Tumor Necrosis Factor alpha (TNF-α). Upon activation by lipopolysaccharides, TTP binds TNF-α mRNA at AU-rich domains in the 3'-untranslated Region (3'-UTR) and induces deadenylation, thereby destabilizing the mRNA and tagging it for degradation. To produce this effect, TTP recruits other trans-acting factors to its C-terminal domain and mRNA-decay enzymes to its N-terminal domain. TTP is deactivated by phosphorylation driven by mitogen-activated protein kinase-activated protein kinase 2 (MK2) and p53. Therefore, TTP/MK2 regulates the biosynthesis of TNF-α and mediates inflammatory responses involving TNF-α. Knockout of TTP in mice produces arthritis, alopecia, dermatitis, among a range of other phenotypes related to overexpression of TNF-α. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with Human and Mouse. View All» Application Notes: Immunocytochemistry Analysis: A representative lot was used by an independent laboratory to detect Tristetraprolin in human leukocytes. (Brooks, S., et al. (2002). Arthritis and Rheumatism. 46(5):1362–1370.) View All» Control: A431 cell lysate View All» Quality Assurance: Evaluated by Western Blot in A431 cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected Tristetraprolin on 10 µg of A431 cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing PBS without 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P26651 View All» Entrez Gene Number: NP_003398 View All» Gene Symbol:
  • ZFP36

  • G0S24

  • RNF162A

  • TIS11A

  • TTP
    View All» Alternate Names:
    • Tristetraprolin

    • TTP

    • G0/G1 switch regulatory protein 24

    • Growth factor-inducible nuclear protein NUP475

    • Protein TIS11A

    • TIS11

    • Zinc finger protein 36 homolog

    • Zfp-36
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry

      • Immunoprecipitation

      • RNA Binding Protein Immunoprecipitation (RIP)
        View All» UniProt Summary: FUNCTION: Probable regulatory protein with a novel zinc finger structure involved in regulating the response to growth factors. Has been experimentally shown to be able to bind zinc.SUBCELLULAR LOCATION: Nucleus. INDUCTION: By stimulation with various mitogens.SEQUENCE SIMILARITIES: Contains 2 C3H1-type zinc fingers. View All» Product Name: Anti-Tristetraprolin View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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