货号：ABE361

品牌：Merck Millipore

规格：100Ug

目录价：￥6127.00

市场价格：￥5207.95

会员价格：￥4901.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-acetyl-Histone H4 (Lys91) Antibody | ABE361 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Histone H4 acetylated at Lys91. View All» Molecular Weight: ~13 kDa observed View All» Immunogen: KLH-conjugated linear peptide corresponding to human Histone H4 acetylated at Lys91. View All» Background Information: Histones are nuclear proteins that form octameric structures which bind DNA to form units of chromatin called nucleosomes. The family of histones—H2A, H2B, H3, and H4—are key players in gene regulation. They undergo a number of post-translational modifications (PTM) in response to various stimuli. Acetylation is a reversible PTM that involves the transfer of acetyl groups to N-terminal lysine (K) residues by the family of histone acetyltransferase enzymes, including GNAT, Gcn5, and p300/CBP. Histone acetylation reduces the electrostatic attractions between DNA and histones, which typically destabilizes chromatin structure and provide chromatin remodeling and transcriptional complexes with access to DNA, potentially resulting in increased gene transcription. Recent studies have suggested that acetylation of histone H4 lysine 91 facilitates the interaction of H3/H4 tetramers with H2A/H2B dimers, which is required for chromatin assembly. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. Expected to react with most mammals due to conserved homology. View All» Application Notes: Dot Blot Analysis: A representative lot detected acetylated Histone H4 (Lys91) in an AbSurance™ Histone H2A, H2B, H4 Antibody Specificity Array (Cat. No. 16-665). View All» Control: Untreated and sodium butyrate treated HeLa acid extract and recombinant Histone H4 View All» Quality Assurance: Evaluated by Western Blot in untreated and sodium butyrate treated HeLa acid extract and recombinant Histone H4.Western Blot Analysis: A 1:2,000 dilution from a representative lot detected acetylated Histone H4 (Lys91) in 10 µg of sodium butyrate treated HeLa acid extract. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P62805 View All» Entrez Gene Number: NP_003486 View All» Gene Symbol:

• HIST1H4A

• H4/A

• H4FA

• HIST1H4B

• H4/I

• H4FI

• HIST1H4C

• H4/G, H4FG

• HIST1H4D

• H4/B

• H4FB

• HIST1H4E

• H4/J

• H4FJ

• HIST1H4F

• H4/C

• H4FC

• HIST1H4H

• H4/H

• H4FH

• HIST1H4I

• H4/M

• H4FM

• HIST1H4J

• H4/E

• H4FE

• HIST1H4K

• H4/D

• H4FD

• HIST1H4L

• H4/K

• H4FK

• HIST2H4A

• H4/N

• H4F2

• H4FN

• HIST2H4

• HIST2H4B

• H4/O

• H4FO

• HIST4H4
  View All» Alternate Names: Histone H4 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Western Blotting

  • Dot Blot
    View All» Product Name: Anti-acetyl-Histone H4 (Lys91) View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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