货号：ABE374

品牌：Merck Millipore

规格：100Ug

目录价：￥4438.00

市场价格：￥3772.30

会员价格：￥3550.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-DAZ Antibody | ABE374 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the N-terminus of DAZ. This antibody demonstrates cross-reactivity with DAZ2, DAZ3, DAZ4, and DAZL each of which contains repeats of the DAZ gene. View All» Molecular Weight: ~83 kDa calculated. Additional bands due to polymorphic expression of DAZ as well as cross-reactivity with DAZ2, DAZ3, DAZ4, and DAZL with calculated molecular weights of ~33 kDa, 37 kDa, 75 kDa, and 100 kDa may be observed in some cell lysates (Poongothai, J., et al. (2009). Singapore Med J. 50(4):336-347; Kim, B., et al. (2009). Hum Reprod. 24(6):1507-1515). This antibody detects DAZ proteins at ~36 kDa, ~80 kDa, and ~105 kDa. View All» Epitope: N-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to the N-terminus of human DAZ. View All» Background Information: DAZ is an RNA-binding protein that belongs to the DAZ family of proteins required for normal growth, development, and fertility. The DAZ family of proteins have one or more RNA recognition motif (RRM) domains and multiple DAZ repeats. Mammalian DAZ is widely expressed in adults with high levels of expression in testis. Frequent deletion of the DAZ genes suggests that DAZ plays an important role in spermatogenesis. It was even proposed that DAZ family proteins are involved in mRNA metabolism during spermatogenesis. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Chimpanzee

• Horse

• Bovine

• Rhesus Macaque

• Pig
  View All» Species Reactivity Note: Demonstrated to react with Human, Mouse, and Rat. Predicted to react with Chimpanzee, Equine, Bovine, Rhesus Macaque, and Porcine. View All» Application Notes: Immunohistochemistry Analysis: A 1:400 dilution from a representative lot detected DAZ in human testis tissue. View All» Control: Human testis tissue lysate. View All» Quality Assurance: Evaluated by Western Blot in human testis tissue lysate.Western Blot Analysis: 1 µg/mL dilution of this antibody detected DAZ in 10 µg of human testis tissue lysate. View All» Purification Method: Affinity Purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9NQZ3 View All» Entrez Gene Number: NP_004072.3 View All» Gene Symbol:
  • DAZ1

  • DAZ

  • SPGY
    View All» Alternate Names: Deleted in azoospermia protein 1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry (Paraffin)
      View All» Entrez Gene Summary: This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains three copies of the 10.8 kb repeat. However, no transcripts containing three copies of the RRM domain have been described; thus the RefSeq for this gene contains only two RRM domains. View All» UniProt Summary: FUNCTION: RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation. Promotes germ-cell progression to meiosis and formation of haploid germ cells.SUBUNIT STRUCTURE: Forms a heterodimer with BOLL and DAZL. Interacts with PUM2, DAZAP1, DAZAP2, DZIP1 and DZIP3.SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note: Predominantly cytoplasmic. Nuclear at some stages of spermatozoide development. Localizes both to the nuclei and cytoplasm of spermatozoide differentiation. Nuclear in fetal gonocytes and in spermatogonial nuclei. It then relocates to the cytoplasm during male meiosis.TISSUE SPECIFICITY: Testis-specific. Expression restricted to premeiotic germ cells, particularly in spermatogonia (at protein level). View All» Product Name: Anti-DAZ View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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