货号：ABE43

品牌：Merck Millipore

规格：100UL

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Ebp1 N-terminal Antibody | ABE43 View All» Replaces: 07-397 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Recognizes Ebp-1. View All» Molecular Weight: 48 kDa Observed View All» Epitope: N-terminus View All» Immunogen: Linear Peptide corresponding to the N-terminus of Ebp1. View All» Isotype: IgG View All» Background Information: Ebp1 is an RNA-binding protein involved in growth regulation. In cancer cells, this protein and has been implicated in growth inhibition and differentiation. Ebp1 is known to bind ribosomal and double-stranded RNA. It is a found in pre-ribosomal ribonucleoprotein complexes and is believed to play a role in ribosome assembly and rRNA processing. This protein is also a component of cytoplasmic bcl-2 messenger ribonucleoprotein. Through interactions with histion deacetylases, this protein can act transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes. Ebp1 also interacts with the cytoplasmic domain of the ErbB3 receptor, potentially transducing regulatory growth signals. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Tested and passed on Human, Mouse, and Rat. View All» Application Notes: Immunocytochemistry: A 1:500 dilution from a representative lot detected Ebp1 in NIH/3T3, A431, and HeLa cells. View All» Control: A431 Cell Lysate. View All» Quality Assurance: Evaluated by Western Blotting in A431 cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit Polyclonal Serum with 0.05% sodium azide View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q9UQ80 View All» Entrez Gene Number: NP_006182 View All» Gene Symbol:
  • EBP1

  • HG4-1

  • p38-2G4

  • PA2G4
    View All» Alternate Names:
    • Proliferation-associated protein 2G4

    • Cell cycle protein p38-2G4 homolog

    • hG4-1

    • ErbB3-binding protein 1

    • Cell cycle protein p38-2G4 homolog

    • ErbB-3 binding protein 1

    • ErbB3-binding protein Ebp1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry
        View All» Entrez Gene Summary: This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified. [provided by RefSeq] View All» UniProt Summary: Function: May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) By similarity. Ref.8 Ref.10 Ref.11 Ref.12Subunit structure: Interacts with the cytoplasmic domain of non-phosphorylated ERBB3; the interaction requires PKC activity. Interacts with AR. Treatment with HRG leads to dissociation from ERBB3 and increases association with AR. Interacts with NCL/nucleolin. Component of a ribonucleoprotein complex containing at least PA2G4, NCL, TOP1, PABPC2, RPLP0, acetylated histone H1 (HIST1H1A or H1F1), histone H1 2/4, RPL4, RPL8, RPL15, RPL18, RPL18A, RPL21, RPL11, RPL12, RPL28, RPL27, RPLP2 and RPL24. Interacts with HDAC2. Interacts with RB1; the interaction is enhanced upon PA2G4 dephosphorylation. Ref.8 Ref.10 Ref.12 Ref.2 Ref.7 Ref.19Subcellular location: Cytoplasm. Nucleus › nucleolus. Note: Tranlocates to the nucleus upon treatment with HRG. Ref.11 Ref.2 Ref.9Tissue specificity: Expressed in several cell lines tested, including primary and transformed cell lines. Ref.11Post-translational modification: Phosphorylated on serine and threonine residues. Phosphorylation is enhanced by HRG treatment. Basal phosphorylation is PKC-dependent and HRG-induced phosphorylation is predominantly PKC-independent. Ref.7 Ref.13 Ref.14 Ref.15 Ref.17 Ref.18Miscellaneous: Does not contain metal cofactors and does not have aminopeptidase activity.Sequence similarities: Belongs to the peptidase M24 family. View All» Product Name: Anti-Ebp1 N-terminal Antibody View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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