货号：ABE48

品牌：Merck Millipore

规格：100Ug

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-NELF-E Antibody | ABE48 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~ 43 kDa observed. Uncharacterized bands may be due to post-translational modification. View All» Immunogen: KLH-conjugated linear peptide corresponding to human NELF-E. View All» Background Information: NELF-E (Negative elongation factor E) is a main component of NELF human transcription factor complex which associates with DRB sensitivity-inducing factor to stifle transcriptional elongation by RNA polymerase II. NELF-E is an RNA-binding protein that includes arginine-aspartic acid dipeptide repeats. NELF-E RNA-binding activity is essential for NELF to function. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Canine

• Bovine
  View All» Species Reactivity Note: Demonstrated to react with Human, Mouse, and Rat. Predicted to react with Canine and Bovine based on 100% sequence homology. View All» Application Notes: Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected NELF-E in NIH/3T3 and HeLa cells. View All» Control: L6 cell lysate View All» Quality Assurance: Evaluated by Western Blot in L6 cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected NELF-E on 10 µg of L6 cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P18615 View All» Entrez Gene Number: NP_002895 View All» Gene Symbol:
  • RDBP

  • NELFE

  • RD
    View All» Alternate Names:
    • Negative elongation factor E

    • NELF-E

    • RNA-binding protein RD
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunocytochemistry

      • Western Blotting
        View All» Entrez Gene Summary: The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. SUBUNIT STRUCTURE: The NELF complex is composed of 4 subunits: WHSC2/NELF-A, COBRA1/NELF-B, TH1L (isoform NELF-C or isoform NELF-D) and RDBP/NELF-E.SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICTY: Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal muscle, kidney and pancreas. DOMAIN: The RRM domain interacts with RNA, and is essential for NELF complex function. It is however not required for the NELF complex formation. Ref.9PTM: Sumoylated. SEQUENCE SIMILARITIES: Belongs to the RRM NELF-E family.Contains 1 RRM (RNA recognition motif) domain. View All» Product Name: Anti-NELF-E View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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