货号：ABE57

品牌：Merck Millipore

规格：

目录价：￥3639.00

市场价格：￥3093.15

会员价格：￥2911.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-LMX-1.2 Antibody | ABE57 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~ 42 kDa observed View All» Immunogen: KLH-conjugated linear peptide corresponding to human LMX-1.2. View All» Isotype: IgG View All» Background Information: LIM/homeobox protein 1.2 (LMX-1.2) belongs to the LIM homeodomain protein family and is comprised of 2 LIM zinc-binding domains and a single homeobox DNA-binding domain. LMX-1.2 is a required for determination of dorsal limb fate at the autopodal and zeugopodal levels during development, and is necessary for the normal development of eye, kidney, and skull. Expression is reported in the majority of tissues, with highest observed levels found in duodenum, pancreatic islets, skeletal muscle, testis, and thyroid. It is observed in the CNS, specifically is the isthmus, developing dopenergic and serotonergic neurons within the midgrain and hindbrain, roof and floor plate of the neural tube, and in a small group of dorsal spinal chord interneurons. Defects in expression causes nail-patella syndrome (NPS) which results in renal dysplasia and aberrant skeletal patterning. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Application Notes: Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in IH. (Dreyer, S. D., et al. (2000). Human Molecular Genetics. 9(7):1067-1074). View All» Control: Human fetal skeletal muscle tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human fetal skeletal muscle tissue lysate.Western Blot Analysis: 1:1,000 dilution of this antibody detected LMX-1.2 on 10 µg of human fetal skeletal muscle tissue lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit polyclonal serum containing 0.5% sodium azide. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: O60663 View All» Entrez Gene Number: NP_002307 View All» Gene Symbol:

• LMX1B

• LMX1.2

• LMX-1.2

• NPS1
  View All» Alternate Names:
  • LIM homeobox transcription factor 1, beta1

  • LIM/homeobox protein LMX1B

  • LIM/homeobox protein 1.2

  • LIM homeobox transcription factor 1-beta
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry
      View All» Entrez Gene Summary: This gene encodes a member of LIM-homeodomain family of proteins containing two N-terminal zinc-binding LIM domains, 1 homeodomain, and a C-terminal glutamine-rich domain. It functions as a transcription factor, and is essential for the normal development of dorsal limb structures, the glomerular basement membrane, the anterior segment of the eye, and dopaminergic and serotonergic neurons. Mutations in this gene are associated with nail-patella syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels.SUBCELLULAR LOCATION: Nucleus Potential. TISSUE SPECIFICTY: Expressed in most tissues. Highest levels in testis, thyroid, duodenum, skeletal muscle, and pancreatic islets.INVOLVEMENT IN DISEASE: Defects in LMX1B are the cause of nail-patella syndrome (NPS) [MIM:161200]; also known as onychoosteodysplasia. NPS is a disease that cause abnormal skeletal patterning and renal dysplasia. SEQUENCE SIMILARITIES: Contains 1 homeobox DNA-binding domain.Contains 2 LIM zinc-binding domains.SEQUENCE CAUTION: The sequence CAH70294.1 differs from that shown. Reason: Erroneous initiation. The sequence CAI40917.1 differs from that shown. Reason: Erroneous initiation. View All» Product Name: Anti-LMX-1.2 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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