货号：ABE69

品牌：Merck Millipore

规格：

目录价：￥4626.00

市场价格：￥3932.10

会员价格：￥3700.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PTIP Antibody | ABE69 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~120 kDa observed. Other isoforms may be observed in some lysates. View All» Immunogen: Histidine-tagged recombinant protein corresponding to human PTIP. View All» Background Information: PAX transactivation activation domain-interacting protein (PTIP) is a ubiquitous nuclear protein composed of 5 tandem BRCA1 carboxyl-terminal (BRCT) domains. PTIP was initially identified as an interacting, transactivation protein that binds to the C-terminal end of Pax2. Since its discovery, studies have shown PTIP to bind several Pax proteins, playing a critical role in response to DNA damage. It also has activity as a phosphoserine/ phosphothreonine-specific binding module, and can discern ATM and ATR gamma irradiation induced phosphorylated substrates. PTIP is involved in early cellular development and is likely to have a role in cell proliferation as well. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with human, mouse, and rat. View All» Application Notes: Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in IH (Patel, S., et al. (2007).Immunofluorescence Analysis: A represenative lot was used by an independent laboratory in IF (Lechner, M., et al. (2000). View All» Control: A431 cell lysate View All» Quality Assurance: Evaluated by Western Blot in A431 cell lysate.Western Blot Analysis: A 1:1,000 dilution of this antibody detected PTIP in 10 µg of A431 cell lysate. View All» Purification Method: Affinity Purified View All» Presentation: Purified chicken polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q6ZW49 View All» Entrez Gene Number: NP_031375 View All» Gene Symbol:
  • PAXIP1L

  • PTIP

  • PAXIP1

  • TNRC2

  • CAGF28

  • PACIP1

  • CAGF29
    View All» Alternate Names:
    • PAX interacting (with transcription-activation domain) protein 1

    • PAX transactivation activation domain-interacting protein

    • protein encoded by CAG trinucleotide repeats

    • PAX transcription activation domain interacting protein 1 like
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry

      • Immunofluorescence
        View All» Entrez Gene Summary: This gene is a member of the paired box (PAX) gene family and encodes a nuclear protein with six BRCT (breast cancer carboxy-terminal) domains. This protein plays a critical role in maintaining genome stability, condensation of chromatin and progression through mitosis. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Functions as a key component of the DNA damage response. Functions as phosphoserine or phosphothreonine-specific binding modules. Recognizes substrates phosphorylated by the kinases ataxia telangiectasia-mutated (ATM), ataxia telangiectasia and RAD3-related (ATR) in response to gamma irradiation. May play a role in PAX2-dependent transcriptional regulation. Plays a role in early development, most probably in cell proliferation. SUBUNIT STRUCTURE: Interacts with the C-terminal transactivation domain of PAX2 (By similarity). Interacts with C16orf53/PA1; the interaction is direct. Component of the MLL3/MLL4 complex, at least composed of MLL3, MLL4, ASH2L, RBBP5, DPY30, WDR5, NCOA6, KDM6A, PAXIP1/PTIP and C16orf53/PA1. Some fraction of the complex contains MLL2 instead of MLL4 and is named MLL2/MLL3 complex.SUBCELLULAR LOCATION: Nucleus membrane; Peripheral membrane protein; Matrix side (By similarity). DOMAIN: The BRCT domains function as a single module and are necessary and sufficient for phospho-specific binding.SEQUENCE SIMILARITIES: Contains 5 BRCT domains.SEQUENCE CAUTION: The sequence AAB91434.1 differs from that shown. Reason: Frameshift at positions 609 and 628. The sequence AAP21865.1 differs from that shown. Reason: Erroneous gene model prediction. View All» Product Name: Anti-PTIP View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Chicken View All»
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