货号：ABE90

品牌：Merck Millipore

规格：EA

目录价：￥4410.00

市场价格：￥3748.50

会员价格：￥3528.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-JMJD7 Antibody | ABE90 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes JJMJD7 at the JmjC domain. View All» Molecular Weight: ~33 kDa observed View All» Epitope: JmjC domain View All» Immunogen: KLH-conjugated linear peptide corresponding to human JMJD7. View All» Background Information: Covalent modification and methylation of histones are crucial regulators of chromatin dynamics and DNA transcription. JMJD7, a member of a family of JMJC domain-containing histone demethylases, is directly involved in removing methyl residues from distinct and unique lysine residues. These actions are thought to have a role in gene expression and the regulation of cell senescence. JMJC domain-containing histone demethylases are also likely involved in development via their ability to regulate gene expression. Methylation of certain lysine residues on Histone H3 and H4 are often associated with transcriptionally active or inactive chromatin which can have profound effects on the expression of genes. JMJD7 contains one JMJC domain and initially thought to be an alternatively spliced isoform of PLA2G4B. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Chimpanzee

• Horse

• Rhesus Macaque
  View All» Species Reactivity Note: Demonstrated to react with Human, Mouse, and Rat. Predicted to react with Chimpanzee, Equine, Rhesus Macaque, Marmoset, and Orangutan based on 100% sequence homology. View All» Control: Raji cell lysate View All» Quality Assurance: Evaluated by Western Blot in Raji cell lysate.Western Blot Analysis: 0.1 µg/mL of this antibody detected JMJD7 on 10 µg of Raji cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P0C870 View All» Entrez Gene Number: NP_001108104 View All» Gene Symbol: JMJD7 View All» Alternate Names:
  • JMJD

  • JmjC domain-containing protein 7

  • Jumonji domain-containing protein 7
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a highly conserved protein with a JmjC domain, which are part of the cupin metalloenzyme superfamily. JmjC proteins may function as 2-oxoglutarate-Fe(II)-dependent dioxygenases. Most tissues also express read-through transcripts from this gene into the downstream phospholipase A2, group IVB (cytosolic) gene, some of which may encode fusion proteins combining the N-terminus of this protein with the phospholipase A2, group IVB protein. [provided by RefSeq]. View All» UniProt Summary: SEQUENCE SIMILARITIES: Contains 1 JmjC domain.CAUTION: This sequence was first thought to be an alternatively spliced isoform of PLA2G4B. It is derived from JMJD7 which is located upstream of PLA2G4B. Most tissues also express read-through transcripts from JMJD7 into the downstream PLA2G4B gene, some of which may encode fusion proteins combining the N-terminus of this protein with PLA2G4B protein. View All» Product Name: Anti-JMJD7 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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