货号：ABN102

品牌：Merck Millipore

规格：100UL

目录价：￥3999.00

市场价格：￥3399.15

会员价格：￥3199.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-GLT1 (N-terminus) Antibody | ABN102 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes GLT1 at the N-terminus. View All» Molecular Weight: ~64 kDa observed. Uniprot describes three isoforms at 60, 61, and 62 kDa. Uncharacterized bands appear at ~80 and ~81 kDa in some lysates. View All» Epitope: N-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to the N-terminus of mouse GLT1. View All» Background Information: Glutamate is the predominant excitatory neurotransmitter in the CNS. It activates ionotropic and metabotropic glutamatergic receptors that mediate a wide range of neural processes including cognition and neural development. Glutamatergic signaling is terminated by the rapid removal of glutamate from the synaptic cleft. GLT-1 (EAAT2; Glutamate/aspartate transporter II) is a member of the family of high-affinity glutamate transporters involved in the reuptake of glutamate. GLT-1 is localized mainly on astrocytes of the forebrain, and transports glutamate in a sodium-dependent manner across an electrochemical gradient. Disruption of GLT-1 function results in accumulation of glutamate and overactivation of glutamatergic receptors, which may lead to neurotoxicity. GLT-1 may contribute to a wide range of disease conditions such as Alzheimer’s disease, Amyotropic Lateral Sclerosis, ischemic stroke, and morphine dependence. View All» Species Reactivity: Mouse View All» Species Reactivity Note: Demonstrated to react with Mouse. Predicted to react with Rat based on 100% sequence homology. Other homologies: 77% homology to Human. View All» Application Notes: Immunoprecipitation Analysis: 10 µg of this antibody immunoprecipitated GLT1 from mouse brain tissue lysate. View All» Control: Mouse brain tissue lysate View All» Quality Assurance: Evaluated by Western Blot in mouse brain tissue lysate.Western Blot Analysis: a 1:10,000 dilution of this antibody detected GLT1 on 10 µg of mouse brain tissue lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P43006 View All» Entrez Gene Number: NP_001070982 View All» Gene Symbol:

• Slc1a2

• Eaat2

• Glt1
  View All» Alternate Names:
  • Excitatory amino acid transporter 2

  • GLT-1

  • Sodium-dependent glutamate/aspartate transporter 2

  • Solute carrier family 1 member 2
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunoprecipitation
      View All» Product Name: Anti-GLT1 (N-terminus) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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