Merck Millipore代理ABN11 Anti-Ca(v)1.3 alpha1 subunit

2025-06-28

货号:ABN11

品牌:Merck Millipore

规格:

目录价:¥4439.00

市场价格:¥3773.15

会员价格:¥3551.20

金山科研平台,产品价格货期咨询微信:jinshanbio Description: Anti-Ca(v)1.3 alpha1 subunit Antibody | ABN11 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Ca(v) 1.3 alpha1 subunit at the N-terminus. View All» Molecular Weight: ~260 kDa observed. The calculated molecular weight is 247 kDa. UniProt describes 13 isoforms produced by alternative splicing. View All» Epitope: N-terminus View All» Immunogen: GST-tagged recombinant protein corresponding to the N-terminus sequence of rat Ca(v) 1.3 alpha1 subunit. View All» Background Information: Ca(v) 1.3 alpha1 subunit is a part of the Ca(v) 1.3 voltage-gated Ca2+ channel, which has become of key importance in regulating Ca2+ at excitatory synapses. The Ca(v) 1.3 channel controls neurotransmitter release from inner hair cells, release of insulin in the pancreas and pace-making activity in the heart. The Ca(v) 1.3 alpha1 subunit interacts with PDZ and is thought to regulate the activity of the Ca(v) 1.3 channel. View All» Species Reactivity:

  • Human

  • Rat

    View All» Species Reactivity Note: Demonstrated to react with Human and Rat. Other homologies: Canine (88% sequence homology), Mouse (73% sequence homology). View All» Application Notes: Western Blot Analysis: 0.1 µg/mL from a representative lot detected Ca(v) 1.3 alpha1 subunit on 10 µg of rat brain tissue lysate.Immunoprecipitation Analysis: A representative lot was used by an independent laboratory in IP. (Calin-Jageman, I., et al. (2007). J Neurosci. 27(6):1374-1385.)Immunocytochemistry Analysis: A representative lot was used by an independent laboratory in IC. (Calin-Jageman, I., et al. (2007). J Neurosci. 27(6):1374-1385.) View All» Control: Human hyperplastic prostate tissue View All» Quality Assurance: Evaluated by Immunohistochemistry Analysis in human hyperplastic prostate tissue.Immunohistochemistry Analysis: 1:200 dilution of this antibody detected Ca(v) 1.3 alpha subunit in human hyperplastic prostate tissue. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P27732 View All» Entrez Gene Number: NP_058994 View All» Gene Symbol:
    • Cacna1d

    • Cach3

    • Cacn4

    • Cacnl1a2

    • Cchl1a2

      View All» Alternate Names:
      • Voltage-dependent L-type calcium channel subunit alpha-1D

      • Calcium channel, L type, alpha-1 polypeptide, isoform 2

      • Rat brain class D

      • RBD

      • Voltage-gated calcium channel subunit alpha Cav1.3

        View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
        • Immunohistochemistry (Paraffin)

        • Western Blotting

          View All» Entrez Gene Summary: Has high voltage L-type calcium channel activity that is sensitive to dihydropyridines [RGD]. View All» UniProt Summary: FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). SUBUNIT STRUCTURE: Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts with CABP1 and CABP4, resulting in a near elimination of calcium-dependent inactivation of the channel. Interacts with RIMBP2 (By similarity). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in brain, pancreatic islets and B-lymphocytes. DOMAIN: Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.SEQUENCE SIMILARITIES: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily. [View classification] View All» Product Name: Anti-Ca(v)1.3 alpha1 subunit View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»

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