货号：ABN161

品牌：Merck Millipore

规格：

目录价：￥4095.00

市场价格：￥3480.75

会员价格：￥3276.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-pan Neurexin-1 Antibody | ABN161 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Pan Neurexin 1 and there is a 75% overlap with Neurexin 2 and 3. View All» Molecular Weight: ~160 kDa observed View All» Epitope: C terminus, 100% conserved between alpha and beta versions of Neurexin 1. View All» Immunogen: KLH-conjugated linear peptide corresponding to human pan Neurexin-1-alpha. View All» Background Information: Neurexin (NRXN) is a presynaptic single pass transmembrane protein that assists in joining neurons together at the synapse. Neurexins mediate signaling across the synapse and neural networks by specifying synpatic function. Studies have shown mutations in the genese encoding for neurexins are impicated in autism, schizphrenia, and nicotine dependence. There are two classifications of neurexins, α-NRXNs and β-NRXNs. The α-NRXNs are larger and have different amino-terminal extracellular sequences than β-NRXNs. β-NRXNs acta as receptors for neuroligin and has been found to play a role in angiogenesis. Pan-neurexin antibodies recognize all neurexin isoforms. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Human, Mouse, and Rat. View All» Application Notes: Immunohistochemistry Analysis: A 1:500-1:1,000 dilution from a representative lot detected pan Neurexin-1-alpha in normal mouse cerebellum and normal rat cerebellum tissues.Immunocytochemistry Analysis: A representative lot was used by an independent laboratory in E18 chicken embryo arteries. (Bottos, A., et al. (2009). Proc Natl Acad Sci USA. 106(49):20782-20787.)Immunoprecipitation Analysis: A representative lot was used by an independent laboratory in E18 chicken brain arteries. (Bottos, A., et al. (2009). Proc Natl Acad Sci USA. 106(49):20782-20787.) View All» Control: Mouse brain membrane tissue lysate View All» Quality Assurance: Evaluated by Western Blot in mouse brain membrane tissue lysate.Western Blot Analysis: A 1:1,000 dilution of this antibody detected pan Neurexin-1-alpha on 10 µg of mouse brain membrane tissue lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in preservative free buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q9ULB1 View All» Entrez Gene Number: NP_001129131 View All» Gene Symbol: NRXN1 View All» Alternate Names:
  • Neurexin-1-alpha

  • Neurexin I-alpha
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry

    • Immunocytochemistry

    • Immunoprecipitation
      View All» Entrez Gene Summary: Neurexins function in the vertebrate nervous system as cell adhesion molecules and receptors. Two neurexin genes are among the largest known in human (NRXN1 and NRXN3). By using alternate promoters, splice sites and exons, predictions of hundreds or even thousands of distinct mRNAs have been made. Most transcripts use the upstream promoter and encode alpha-neurexin isoforms; fewer transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. Alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and they interact with neurexophilins. Beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. The RefSeq Project has decided to create only a few representative transcript variants of the multitude that are possible. [provided by RefSeq, Oct 2008]. View All» UniProt Summary: FUNCTION: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.SUBUNIT STRUCTURE: The cytoplasmic C-terminal region binds to CASK, CASKIN1 and APBA1. The laminin G-like domain 2 binds to NXPH1. Specific isoforms bind to alpha-dystroglycan and to alpha-latroxin. Interacts with SYT13 and SYTL1 (By similarity).SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential). TISSUE SPECIFICITY: Heart and brain.PTM: N- and O-glycosylated (By similarity).SEQUENCE SIMILARITIES: Belongs to the neurexin family.Contains 3 EGF-like domains.Contains 6 laminin G-like domains.SEQUENCE CAUTION: The sequence BAA25504.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. View All» Product Name: Anti-pan Neurexin-1 View All» Concentration: 0.6 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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