货号：ABN19

品牌：Merck Millipore

规格：EA

目录价：￥4041.00

市场价格：￥3434.85

会员价格：￥3232.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-GST M1(mu) Antibody | ABN19 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes GST M1 at and around the C-terminus. This antibody will react against both Isoforms. View All» Molecular Weight: ~ 26 kDa; an unknown band of ~180 kDa was also observed. View All» Epitope: C-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to human GST M1 at and around the C-terminus. View All» Background Information: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. View All» Species Reactivity:

• Human

• Monkey

• Chimpanzee
  View All» Species Reactivity Note: Proven to react with human. Predicted to react with monkey, chimpanzee, and rhesus monkey based on 100% sequence homology. View All» Control: Human liver tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human liver tissue lysate.Western Blot Analysis: 1 µg/ml of this antibody detected GST M1 in 10 µg of human liver tissue lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P09488 View All» Entrez Gene Number: NP_000552 View All» Gene Symbol:
  • GSTM1

  • GSTM1-1

  • GSTM1b-1b

  • GSTM1a-1a

  • MU

  • MU-1

  • GST1

  • H-B

  • GTH4

  • GTM1
    View All» Alternate Names:
    • GST class-mu 1

    • HB subunit 4

    • S-(hydroxyalkyl)glutathione lyase

    • glutathione S-alkyltransferase

    • glutathione S-aralkyltransferase

    • glutathione S-aryltransferase

    • glutathione S-transferase M1

    • glutathione S-transferase mu 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.SIZE: 218 amino acids; 25712 Da SUBUNIT: Homodimer.SUBCELLULAR LOCATION: Cytoplasm.TISSUE SPECIFICITY: Liver.SIMILARITY: Belongs to the GST superfamily. Mu family. View All» Product Name: Anti-GST M1(mu) View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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