货号：ABN194

品牌：Merck Millipore

规格：100Ug

目录价：￥4452.00

市场价格：￥3784.20

会员价格：￥3561.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-EVI-5 Antibody | Cat. No. ABN194 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~95 kDa observed. Uncharacterized bands may be observed at ~31 kDa, ~17 kDa, and ~15 kDa in some cell lysates. This protein is known to have three potential phosphorylation sites. View All» Immunogen: KLH-conjugated linear peptide corresponding to the human EVI-5. View All» Background Information: Also known as Ecotropic viral integration site 5 protein homolog, EVI-5 serves as a key regulator of the cell cycle through time-dependent stabilization of Emi1, FBX05 protein, and APC/C ubiquitination substrates, such as cyclin A. EVI-5 accumulates in early G1 following Plk1 destruction, but is degraded in a Plk1- and ubiquitin-dependent manner in early mitosis. EVI-5 ablation causes premature APC/C activation, SCF(betaTrCP)-dependent Emi1 degradation, and cyclin destruction, all of which leads to cell cycle arrest and cytokinesis failure. It exists as a monomer and a dimer, and it may form complexes with alpha- and gamma-tubulin or interact with the INCENP-aurora B kinase-survivin chromosomal passenger complex. EVI-5 is implicated in abnormal states, such as multiple sclerosis and neuroblastoma. View All» Species Reactivity:

• Mouse

• Rat

• Human
  View All» Species Reactivity Note: Demonstrated to react with Mouse and Rat. Predicted to react with Human based upon immunogen design. View All» Application Notes: Western Blot Analysis: 2 µg/mL from a representative lot detected EVI-5 in NIH/3T3 nuclear extract. View All» Control: Mouse and rat brain tissues View All» Quality Assurance: Evaluated by Immunohistochemistry in mouse and rat brain tissues.Immunohistochemistry Analysis: A 1:500 dilution of this antibody detected EVI-5 in mouse and rat brain tissues. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O60447 View All» Entrez Gene Number: NP_005656 View All» Gene Symbol:
  • EVI5

  • NB4S
    View All» Alternate Names:
    • Ecotropic viral integration site 5 protein homolog

    • EVI-5
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunohistochemistry

      • Western Blotting
        View All» Product Name: Anti-EVI-5 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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