货号：ABN20

品牌：Merck Millipore

规格：100Ug

目录价：￥6434.00

市场价格：￥5468.90

会员价格：￥5147.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Dopamine D(1A) Receptor Antibody | ABN20 View All» Replaces: AB1765P; View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes D(1A) dopamine receptor. View All» Molecular Weight: ~ 55 kDa is observed View All» Epitope: Cytoplasmic Domain View All» Immunogen: KLH-conjugated linear peptide of rat dopamine D(1A) receptor at and around the cytoplasmic domain. View All» Background Information: Dopaminergic signals are thought to modulate corticostriatal synapses onto medium spiny projection neurons, and this plasticity is, in turn, thought to alter patterns of activity during learning. Subversion of these processes in clinical and rodent models is hypothesized to contribute importantly to addiction to psychostimulants, seizures, and movement disorders in Huntington’s (HD) and Parkinson’s disease (PD). Dopamine receptor D1, also known as DRD1, is the most abundant dopamine receptor (of the five types D1-D5) in the central nervous system and is critically involved in these processes and the modulation of D2 receptor mediated events. Coupled with G-protein, the D1a receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases including the key molecular switch, DARPP-32. View All» Species Reactivity:

• Rat

• Bovine
  View All» Species Reactivity Note: Demonstrated to react with rat. Predicted to react with bovine based on 100% sequence homology. View All» Application Notes: Immunohistochemistry Analysis: A 1:300 dilution from a previous lot detected D(1A) dopamine receptor in rat brain tissue.ELISA Analysis: Tested in ELISA against antigen-coated plate. A 1:100 dilution from a previous lot detected dopamine D(1A) receptor peptide. View All» Control: Rat testis tissue lysate View All» Quality Assurance: Evaluated by Western Blot in rat testis tissue lysate.Western Blot Analysis: 2 µg/ml of this antibody detected dopamine D(1A) receptor in 10 µg of rat testis tissue lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P18901 View All» Entrez Gene Number: NP_036678 View All» Gene Symbol:
  • D1a

  • Drd1

  • Drd-1

  • Drd1a
    View All» Alternate Names: dopamine receptor D1, D(1A) dopamine receptor View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunohistochemistry

    • Western Blotting

    • ELISA
      View All» Entrez Gene Summary: Induces dopamine sensitive adenylate cyclase activation; plays a role in regulating food intake [RGD]. View All» UniProt Summary: FUNCTION: This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.SUBUNIT STRUCTURE: Interacts with calcyon By similarity. Interacts with DNAJC14 via its C-terminus.SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note: Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14. TISSUE SPECIFICITY: Brain, in the striatum, the nucleus accumbens, and the olfactory tubercle.PTM: N-glycosylated.SEQUENCE SIMILARITIES: Belongs to the G-protein coupled receptor 1 family. View All» Product Name: Anti-Dopamine D(1A) Receptor View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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